1. Gene
  2. SNAP91 - synaptosome associated protein 91 Gene

SNAP91 - synaptosome associated protein 91 Gene

Homo sapiens

Also known as CALM; AP180

Gene ID: 9892 | Gene type: protein coding

About SNAP91

Cytogenetic location: 6q14.2 Genomic coordinates (GRCh38): 6:83,552,885-83,709,393 (from NCBI)

This gene has 22 transcripts (splice variants), 265 orthologues and 1 paralogue. Biased expression in brain (RPKM 42.7), testis (RPKM 6.2) and 1 other tissue.

Summary

Predicted to enable several functions, including SNARE binding activity; clathrin binding activity; and phosphatidylinositol binding activity. Acts upstream of or within regulation of clathrin-dependent endocytosis. Predicted to be located in several cellular components, including postsynaptic density; presynaptic endosome; and presynaptic membrane. Predicted to be extrinsic component of endosome membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and parallel fiber to Purkinje cell synapse. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

SNAP91 Products(68)

mRNA Protein Name
NM_001242792.2 NP_001229721.1 clathrin coat assembly protein AP180 isoform a
NM_001242793.2 NP_001229722.1 clathrin coat assembly protein AP180 isoform b
NM_001242794.2 NP_001229723.1 clathrin coat assembly protein AP180 isoform c
NM_001256717.2 NP_001243646.1 clathrin coat assembly protein AP180 isoform d
NM_001256718.2 NP_001243647.1 clathrin coat assembly protein AP180 isoform e
NM_001363677.2 NP_001350606.1 clathrin coat assembly protein AP180 isoform f
NM_001376675.1 NP_001363604.1 clathrin coat assembly protein AP180 isoform g
NM_001376676.1 NP_001363605.1 clathrin coat assembly protein AP180 isoform g
NM_001376677.1 NP_001363606.1 clathrin coat assembly protein AP180 isoform g
NM_001376678.1 NP_001363607.1 clathrin coat assembly protein AP180 isoform g
NM_001376679.1 NP_001363608.1 clathrin coat assembly protein AP180 isoform g
NM_001376680.1 NP_001363609.1 clathrin coat assembly protein AP180 isoform g
NM_001376681.1 NP_001363610.1 clathrin coat assembly protein AP180 isoform g
NM_001376682.1 NP_001363611.1 clathrin coat assembly protein AP180 isoform g
NM_001376683.1 NP_001363612.1 clathrin coat assembly protein AP180 isoform h
NM_001376684.1 NP_001363613.1 clathrin coat assembly protein AP180 isoform h
NM_001376685.1 NP_001363614.1 clathrin coat assembly protein AP180 isoform i
NM_001376686.1 NP_001363615.1 clathrin coat assembly protein AP180 isoform i
NM_001376687.1 NP_001363616.1 clathrin coat assembly protein AP180 isoform gg
NM_001376688.1 NP_001363617.1 clathrin coat assembly protein AP180 isoform i
NM_001376689.1 NP_001363618.1 clathrin coat assembly protein AP180 isoform i
NM_001376690.1 NP_001363619.1 clathrin coat assembly protein AP180 isoform i
NM_001376691.1 NP_001363620.1 clathrin coat assembly protein AP180 isoform i
NM_001376692.1 NP_001363621.1 clathrin coat assembly protein AP180 isoform i
NM_001376693.1 NP_001363622.1 clathrin coat assembly protein AP180 isoform j
NM_001376694.1 NP_001363623.1 clathrin coat assembly protein AP180 isoform k
NM_001376695.1 NP_001363624.1 clathrin coat assembly protein AP180 isoform l
NM_001376696.1 NP_001363625.1 clathrin coat assembly protein AP180 isoform l
NM_001376697.1 NP_001363626.1 clathrin coat assembly protein AP180 isoform l
NM_001376698.1 NP_001363627.1 clathrin coat assembly protein AP180 isoform l
NM_001376699.1 NP_001363628.1 clathrin coat assembly protein AP180 isoform m
NM_001376700.1 NP_001363629.1 clathrin coat assembly protein AP180 isoform m
NM_001376701.1 NP_001363630.1 clathrin coat assembly protein AP180 isoform n
NM_001376702.1 NP_001363631.1 clathrin coat assembly protein AP180 isoform o
NM_001376703.1 NP_001363632.1 clathrin coat assembly protein AP180 isoform o
NM_001376704.1 NP_001363633.1 clathrin coat assembly protein AP180 isoform o
NM_001376705.1 NP_001363634.1 clathrin coat assembly protein AP180 isoform o
NM_001376706.1 NP_001363635.1 clathrin coat assembly protein AP180 isoform o
NM_001376707.1 NP_001363636.1 clathrin coat assembly protein AP180 isoform o
NM_001376708.1 NP_001363637.1 clathrin coat assembly protein AP180 isoform b
NM_001376709.1 NP_001363638.1 clathrin coat assembly protein AP180 isoform b
NM_001376710.1 NP_001363639.1 clathrin coat assembly protein AP180 isoform b
NM_001376711.1 NP_001363640.1 clathrin coat assembly protein AP180 isoform b
NM_001376712.1 NP_001363641.1 clathrin coat assembly protein AP180 isoform hh
NM_001376713.1 NP_001363642.1 clathrin coat assembly protein AP180 isoform p
NM_001376714.1 NP_001363643.1 clathrin coat assembly protein AP180 isoform p
NM_001376715.1 NP_001363644.1 clathrin coat assembly protein AP180 isoform q
NM_001376716.1 NP_001363645.1 clathrin coat assembly protein AP180 isoform r
NM_001376717.1 NP_001363646.1 clathrin coat assembly protein AP180 isoform s
NM_001376718.1 NP_001363647.1 clathrin coat assembly protein AP180 isoform t
NM_001376719.1 NP_001363648.1 clathrin coat assembly protein AP180 isoform u
NM_001376720.1 NP_001363649.1 clathrin coat assembly protein AP180 isoform v
NM_001376721.1 NP_001363650.1 clathrin coat assembly protein AP180 isoform v
NM_001376723.1 NP_001363652.1 clathrin coat assembly protein AP180 isoform v
NM_001376726.1 NP_001363655.1 clathrin coat assembly protein AP180 isoform v
NM_001376728.1 NP_001363657.1 clathrin coat assembly protein AP180 isoform v
NM_001376731.1 NP_001363660.1 clathrin coat assembly protein AP180 isoform w
NM_001376733.1 NP_001363662.1 clathrin coat assembly protein AP180 isoform x
NM_001376734.1 NP_001363663.1 clathrin coat assembly protein AP180 isoform x
NM_001376735.1 NP_001363664.1 clathrin coat assembly protein AP180 isoform y
NM_001376736.1 NP_001363665.1 clathrin coat assembly protein AP180 isoform z
NM_001376737.1 NP_001363666.1 clathrin coat assembly protein AP180 isoform aa
NM_001376738.1 NP_001363667.1 clathrin coat assembly protein AP180 isoform bb
NM_001376739.1 NP_001363668.1 clathrin coat assembly protein AP180 isoform cc
NM_001376740.1 NP_001363669.1 clathrin coat assembly protein AP180 isoform dd
NM_001376741.1 NP_001363670.1 clathrin coat assembly protein AP180 isoform ee
NM_001376742.1 NP_001363671.1 clathrin coat assembly protein AP180 isoform ff
NM_014841.3 NP_055656.1 clathrin coat assembly protein AP180 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17762867 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within regulation of clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
16254249 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNAP91 Protein Structure

ANTH

ANTH: ANTH domain (21 - 284)

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  • 907 a.a.
Protein Preferred Names Protein Names

clathrin coat assembly protein AP180

91 kDa synaptosomal-associated protein

Related Diseases

Diseases Alias
Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive

Autosomal Recessive Centronuclear Myopathy

CNM2

Centronuclear Myopathy 2

Ar-Cnm

Myotubular Myopathy, Autosomal Recessive

Autosomal Recessive Myotubular Myopathy

Centronuclear Myopathy Autosomal Recessive

Myopathy, Centronuclear, Type 2

Cataract 8, Multiple Types

Ccv

Cataract, Congenital, Volkmann Type

CTRCT8

Cataract 8 Multiple Types

Cataract Congenital Volkmann Type

Cutaneous Collagenous Vasculopathy

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus SNAP91 VGNC VGNC:65518
Rattus norvegicus SNAP91 RGD RGD:69276
Bos taurus SNAP91 VGNC VGNC:59365
Canis familiaris SNAP91 VGNC VGNC:46590
Mus musculus SNAP91 MGD MGI:109132
Macaca mulatta SNAP91 VGNC VGNC:77711