2. Gene
  3. HELZ - helicase with zinc finger Gene

HELZ - helicase with zinc finger Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as DHRC; DRHC; HUMORF5

Gene ID: 9931 | Gene type: protein coding

About HELZ

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:67,070,444-67,245,989 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 6.5), ovary (RPKM 6.3) and 25 other tissues.

Summary

HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]

HELZ Products(2)

mRNA Protein Name
NM_001330447.2 NP_001317376.2 probable helicase with zinc finger domain isoform 2
NM_014877.4 NP_055692.3 probable helicase with zinc finger domain isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24606901 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HELZ Protein Structure

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (181 - 205)

AAA_11

AAA_11: AAA domain (642 - 754)

AAA_11

AAA_11: AAA domain (758 - 833)

AAA_12

AAA_12: AAA domain (841 - 1050)

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  • 1942 a.a.
Protein Preferred Names Protein Names

probable helicase with zinc finger domain

down-regulated in human cancers protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06118 HELZ Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06119 HELZ2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HELZ VGNC VGNC:62792
Macaca mulatta HELZ VGNC VGNC:73178
Rattus norvegicus HELZ RGD RGD:1307049
Canis familiaris HELZ VGNC VGNC:41652
Mus musculus HELZ MGD MGI:1925705
Bos taurus HELZ VGNC VGNC:57142