2. Gene
  3. HS3ST4 - heparan sulfate-glucosamine 3-sulfotransferase 4 Gene

HS3ST4 - heparan sulfate-glucosamine 3-sulfotransferase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 30ST4; 3OST4; 3-OST-4; h3-OST-4

Gene ID: 9951 | Gene type: protein coding

About HS3ST4

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:25,691,959-26,137,685 (from NCBI)

This gene has 2 transcripts (splice variants), 195 orthologues and 10 paralogues. Biased expression in brain (RPKM 7.8), spleen (RPKM 1.0) and 1 other tissue.

Summary

This gene encodes the Enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This Enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. [provided by RefSeq, Jul 2008]

HS3ST4 Products(1)

mRNA Protein Name
NM_006040.3 NP_006031.2 heparan sulfate glucosamine 3-O-sulfotransferase 4

HS3ST4 Protein Structure

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (198 - 433)

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  • 456 a.a.
Protein Preferred Names Protein Names

heparan sulfate glucosamine 3-O-sulfotransferase 4

heparan sulfate (glucosamine) 3-O-sulfotransferase 4

Related Diseases

Diseases Alias
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Herpes Zoster

Shingles

Zoster

Herpes Zona

Herpes Zoster Disease

Zona Zoster

Herpes Zoster Of Skin And Mucous Membranes

Zoster Nos

Zoster With Nervous System Involvement
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-E70172 Heparan Sulfate 3-O-Sulfotransferase 4 Modulator / Unkown
HY-RS06380 HS3ST4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HS3ST4 VGNC VGNC:104731
Rattus norvegicus HS3ST4 RGD RGD:11422907
Felis catus HS3ST4 VGNC VGNC:80581
Mus musculus HS3ST4 MGD MGI:1333792