HS3ST1 - heparan sulfate-glucosamine 3-sulfotransferase 1 Gene

Homo sapiens

Also known as 3OST; 3OST1

Gene ID: 9957 | Gene type: protein coding

About HS3ST1

Cytogenetic location: 4p15.33 Genomic coordinates (GRCh38): 4:11,393,150-11,434,327 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues and 10 paralogues. Ubiquitous expression in urinary bladder (RPKM 2.8), gall bladder (RPKM 0.9) and 19 other tissues.

Summary

Heparan sulfate biosynthetic Enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The Enzyme encoded by this gene is a member of the heparan sulfate biosynthetic Enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting Enzyme for synthesis of anticoagulant heparan. This Enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]

HS3ST1 Products(1)

mRNA	Protein	Name
NM_005114.4	NP_005105.1	heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IDA IDA: Inferred from direct assay	8900198	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycosaminoglycan biosynthetic process	IDA IDA: Inferred from direct assay	8900198	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HS3ST1 Protein Structure

Sulfotransfer_1

0
100
200
307 a.a.

Protein Preferred Names

Protein Names

heparan sulfate glucosamine 3-O-sulfotransferase 1

3-OST-1

Recombinant HS3ST1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76974	HS3ST1 Protein, Human (sf9, His)	O14792 (R21-H307)	≥95%

Related Diseases

Diseases

Alias

Arteriosclerosis

Arteriosclerotic Vascular Disease

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Acute Retinal Necrosis Syndrome

Acute Retinal Necrosis

Retinal Necrosis Syndrome, Acute

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06377	HS3ST1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HS3ST1	VGNC	VGNC:73525
Rattus norvegicus	HS3ST1	RGD	RGD:71084
Mus musculus	HS3ST1	MGD	MGI:1201606
Bos taurus	HS3ST1	VGNC	VGNC:29958
Canis familiaris	HS3ST1	VGNC	VGNC:41791
Others	HS3ST1	NCBI

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