2. Gene
  3. USP3 - ubiquitin specific peptidase 3 Gene

USP3 - ubiquitin specific peptidase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as UBP; SIH003

Gene ID: 9960 | Gene type: protein coding

About USP3

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:63,504,593-63,594,633 (from NCBI)

This gene has 21 transcripts (splice variants), 200 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 9.8), spleen (RPKM 5.3) and 25 other tissues.

Summary

Enables histone binding activity and thiol-dependent Deubiquitinase. Involved in several processes, including DNA repair; histone deubiquitination; and regulation of protein stability. Located in several cellular components, including Flemming body; cytoplasmic ribonucleoprotein granule; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

USP3 Products(2)

mRNA Protein Name
NM_001256702.2 NP_001243631.1 ubiquitin carboxyl-terminal hydrolase 3 isoform 2
NM_006537.4 NP_006528.2 ubiquitin carboxyl-terminal hydrolase 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
17980597 GOA
enables histone H2A deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
17980597 GOA
enables histone H2B deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
17980597 GOA
enables histone binding IPI
IPI: Inferred from physical interaction
17980597 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA repair IMP
IMP: Inferred from mutant phenotype
17980597 GOA
involved in DNA repair-dependent chromatin remodeling IDA
IDA: Inferred from direct assay
17980597 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
17980597 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP3 Protein Structure

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (29 - 106)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (159 - 508)

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  • 520 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 3

deubiquitinating enzyme 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15540 USP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-157428 USP3 ZnF-UBD ligand-1 / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus USP3 VGNC VGNC:66877
Macaca mulatta USP3 VGNC VGNC:78746
Mus musculus USP3 MGD MGI:2152450
Canis familiaris USP3 VGNC VGNC:48187
Bos taurus USP3 VGNC VGNC:36721
Rattus norvegicus USP3 RGD RGD:1308852
Others USP3 NCBI