USP3 - ubiquitin specific peptidase 3 Gene

Homo sapiens

Also known as UBP; SIH003

Gene ID: 9960 | Gene type: protein coding

About USP3

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:63,504,593-63,594,633 (from NCBI)

This gene has 21 transcripts (splice variants), 200 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 9.8), spleen (RPKM 5.3) and 25 other tissues.

Summary

Enables histone binding activity and thiol-dependent Deubiquitinase. Involved in several processes, including DNA repair; histone deubiquitination; and regulation of protein stability. Located in several cellular components, including Flemming body; cytoplasmic ribonucleoprotein granule; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

USP3 Products(2)

mRNA	Protein	Name
NM_001256702.2	NP_001243631.1	ubiquitin carboxyl-terminal hydrolase 3 isoform 2
NM_006537.4	NP_006528.2	ubiquitin carboxyl-terminal hydrolase 3 isoform 1

USP3 Protein Structure

zf-UBP

UCH

0
100
200
300
400
520 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 3

deubiquitinating enzyme 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15540	USP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-157428	USP3 ZnF-UBD ligand-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	USP3	VGNC	VGNC:66877
Macaca mulatta	USP3	VGNC	VGNC:78746
Mus musculus	USP3	MGD	MGI:2152450
Canis familiaris	USP3	VGNC	VGNC:48187
Bos taurus	USP3	VGNC	VGNC:36721
Rattus norvegicus	USP3	RGD	RGD:1308852
Others	USP3	NCBI

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