1. Apoptosis
  2. Apoptosis Ferroptosis
  3. GIC-20

GIC-20 is a dual inducer for apoptosis and ferroptosis. GIC-20 exhibits antitumor efficacy against fibrosarcoma.

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GIC-20 Chemical Structure

GIC-20 Chemical Structure

CAS No. : 2942242-60-4

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Description

GIC-20 is a dual inducer for apoptosis and ferroptosis. GIC-20 exhibits antitumor efficacy against fibrosarcoma[1].

In Vitro

GIC-20 (1 μM, 48 h) inhibits proliferation and migration of HT1080 fibrosarcoma cells, exhibits cytotoxicity with IC50 of 1.6 μM[1].
GIC-20 (0.5-4 μM, 24 h) induces ferroptosis by inducing intracellular lipid peroxide and ROS accumulation, or by degradation of GPX4[1].
GIC-20 (0-1 μM, 24 h) inhibits cell viability of drug-resistant MIA-PaCa-2-AMG510R cells, enhances the sensitivity of MIA-PaCa-2-AMG510R cells to AMG510[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HT1080
Concentration: 0-4 μM
Incubation Time: 24 h
Result: Inhibited expression of GPX4 and Bcl-2, promoted expression of Bax.

Apoptosis Analysis[1]

Cell Line: HT1080
Concentration: 0-4 μM
Incubation Time: 24 h
Result: Induced apoptosis in a dose-dependent manner.
In Vivo

GIC-20 (20-40 mg/kg, i.p., once daily for 19 days) exhibits antitumor efficacy in HT1080 xenograft BALB/c mice, without significant toxicity in major organs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HT1080 xenograft BALB/c mice[1]
Dosage: 20-40 mg/kg
Administration: i.p., once a day for 19 days
Result: Inhibited tumor growth, with a TGI of 63% at 40 mg/kg.
Maintained a complete morphology without obvious cellular inflammatory, oedema, or necrosis in major organs.
Molecular Weight

697.24

Formula

C38H37ClN4O5S

CAS No.
SMILES

O=C1C=C(NCCCCCC(NC2=CC=C(N(C(C(NCCC3=CC=CC=C3)=O)C4=CC=CS4)C(CCl)=O)C=C2)=O)C(C5=CC=CC=C51)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
GIC-20
Cat. No.:
HY-162449
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