2. Neuronal Signaling
  3. Serotonin Transporter
  4. Glemanserin

Glemanserin  (Synonyms: MDL11939)

Cat. No.: HY-101250 Purity: ≥98.0%
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Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively).

For research use only. We do not sell to patients.

Glemanserin Chemical Structure

Glemanserin Chemical Structure

CAS No. : 107703-78-6

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

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Description

Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively)[1][2].

In Vivo

Glemanserin (MDL11939) suppresses the induced increase in locomotor activity, behavioral sensitization and withdrawal symptoms in male mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

295.42

Formula

C20H25NO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC=CC=C1)C2CCN(CCC3=CC=CC=C3)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (338.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3850 mL 16.9251 mL 33.8501 mL
5 mM 0.6770 mL 3.3850 mL 6.7700 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3850 mL 16.9251 mL 33.8501 mL 84.6253 mL
5 mM 0.6770 mL 3.3850 mL 6.7700 mL 16.9251 mL
10 mM 0.3385 mL 1.6925 mL 3.3850 mL 8.4625 mL
15 mM 0.2257 mL 1.1283 mL 2.2567 mL 5.6417 mL
20 mM 0.1693 mL 0.8463 mL 1.6925 mL 4.2313 mL
25 mM 0.1354 mL 0.6770 mL 1.3540 mL 3.3850 mL
30 mM 0.1128 mL 0.5642 mL 1.1283 mL 2.8208 mL
40 mM 0.0846 mL 0.4231 mL 0.8463 mL 2.1156 mL
50 mM 0.0677 mL 0.3385 mL 0.6770 mL 1.6925 mL
60 mM 0.0564 mL 0.2821 mL 0.5642 mL 1.4104 mL
80 mM 0.0423 mL 0.2116 mL 0.4231 mL 1.0578 mL
100 mM 0.0339 mL 0.1693 mL 0.3385 mL 0.8463 mL
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Glemanserin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glemanserin107703-78-6MDL11939MDL 11939MDL-11939Serotonin Transporter5-HTTSERTSLC6A4selectivebehavioral sensitizationsymptoms5-HT2A receptorInhibitorinhibitorinhibit

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