Glutathione arsenoxide (Synonyms: GSAO)

Cat. No.: HY-130588: FAQs
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Glutathione arsenoxide (GSAO) is a potential anticancer agent and a tumour metabolism inhibitor. Glutathione arsenoxide targets Mitochondrial endomycin nucleotide transferase (ANT). Glutathione arsenoxide causes cell proliferation arrest and cell death. Glutathione arsenoxide can be used to identify cell-surface proteins, such as Protein disulphide isomerase.

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Glutathione arsenoxide Chemical Structure

CAS No. : 1271726-51-2

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Other Forms of Glutathione arsenoxide:

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Description

IC₅₀ & Target

Mitochondrial endomycin nucleotide transferase (ANT), Protein disulphide isomerase (PDI)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	270 μM Compound: GSAO	Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay	[PMID: 19788237]
HCT-116	IC₅₀	43 μM Compound: GSAO	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 19788237]
HMEC-1	IC₅₀	23 μM Compound: GSAO	Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay	[PMID: 19788237]
HT-1080	IC₅₀	25 μM Compound: GSAO	Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 19788237]
K562	IC₅₀	14 μM Compound: GSAO	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 19788237]
Lewis lung carcinoma cell line	IC₅₀	41 μM Compound: GSAO	Antiproliferative activity against mouse LLC cells after 72 hrs by MTT assay Antiproliferative activity against mouse LLC cells after 72 hrs by MTT assay	[PMID: 19788237]
MCF7	IC₅₀	51 μM Compound: GSAO	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 19788237]
MDCK-II	IC₅₀	13 μM Compound: GSAO	Antiproliferative activity against MDCK2 cells after 72 hrs by MTT assay Antiproliferative activity against MDCK2 cells after 72 hrs by MTT assay	[PMID: 19788237]
PANC-1	IC₅₀	43 μM Compound: GSAO	Antiproliferative activity against human PANC1 cells after 72 hrs by MTT assay Antiproliferative activity against human PANC1 cells after 72 hrs by MTT assay	[PMID: 19788237]

Clinical Trial

Molecular Weight

548.40

Formula

C₁₈H₂₅AsN₄O₉S

CAS No.

1271726-51-2

SMILES

O=C(O)CNC([C@H](CSCC(NC1=CC=C([As](O)O)C=C1)=O)NC(CC[C@@H](C(O)=O)N)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Park D, et al. The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell Int. 2012 Mar 26;12(1):11. [Content Brief]

[2]. Habeck M. Australian scientists design novel antiangiogenic weapon[J]. The Lancet Oncology, 2000, 1(4): 199.

Glutathione arsenoxide Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glutathione arsenoxide1271726-51-2GSAOMitochondrial MetabolismInhibitorinhibitorinhibit

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