2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Endogenous Metabolite iGluR
  4. Glycine-15N

Glycine-15N is the 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[1].

For research use only. We do not sell to patients.

Glycine-<sup>15</sup>N Chemical Structure

Glycine-15N Chemical Structure

CAS No. : 7299-33-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Glycine-15N:

Glycine-15N Related Antibodies

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Description

Glycine-15N is the 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[1].

IC50 & Target

NMDA Receptor

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycine-15N Related Antibodies
Molecular Weight

76.06

Formula

C2H515NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[15NH2]CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (328.69 mM; Need ultrasonic)

H2O : 25 mg/mL (328.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 13.1475 mL 65.7376 mL 131.4752 mL
5 mM 2.6295 mL 13.1475 mL 26.2950 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (243 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O 1 mM 13.1475 mL 65.7376 mL 131.4752 mL 328.6879 mL
5 mM 2.6295 mL 13.1475 mL 26.2950 mL 65.7376 mL
10 mM 1.3148 mL 6.5738 mL 13.1475 mL 32.8688 mL
15 mM 0.8765 mL 4.3825 mL 8.7650 mL 21.9125 mL
20 mM 0.6574 mL 3.2869 mL 6.5738 mL 16.4344 mL
25 mM 0.5259 mL 2.6295 mL 5.2590 mL 13.1475 mL
30 mM 0.4383 mL 2.1913 mL 4.3825 mL 10.9563 mL
40 mM 0.3287 mL 1.6434 mL 3.2869 mL 8.2172 mL
50 mM 0.2630 mL 1.3148 mL 2.6295 mL 6.5738 mL
60 mM 0.2191 mL 1.0956 mL 2.1913 mL 5.4781 mL
80 mM 0.1643 mL 0.8217 mL 1.6434 mL 4.1086 mL
100 mM 0.1315 mL 0.6574 mL 1.3148 mL 3.2869 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Glycine-15N Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycine-15N7299-33-4Endogenous MetaboliteiGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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