2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. GM-60186

GM-60186 is a 5-HT receptor 2B (HTR2B) inhibitor with an IC50 of 257 nM. GM-60186 significantly inhibits colorectal cancer proliferation and migration.

For research use only. We do not sell to patients.

GM-60186 Chemical Structure

GM-60186 Chemical Structure

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GM-60186 Related Antibodies

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Description

GM-60186 is a 5-HT receptor 2B (HTR2B) inhibitor with an IC50 of 257 nM. GM-60186 significantly inhibits colorectal cancer proliferation and migration[1].

IC50 & Target[1]

5-HT2B Receptor

257 nM (IC50)

In Vitro

GM-60186 (50-500 nM; 72 hours) effectively inhibits the proliferation in colorectal cancer (CRC) cells[1].
GM-60186 (500 nM; 24-48 hours) effectively inhibits colorectal cancer migration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GM-60186 Related Antibodies

Cell Viability Assay[1]

Cell Line: COLO-205, MC38, CT26 and Caco2 cells
Concentration: 0, 50, 100, and 500 nM
Incubation Time: 72 hours
Result: Demonstrated effective inhibition of cell proliferation in these CRC cell lines.

Cell Migration Assay [1]

Cell Line: COLO-205, CT26 and MC38 cells
Concentration: 500 nM
Incubation Time: 24, and 48 h
Result: Inhibited colorectal cancer migration.
In Vivo

GM-60186 (10-20 mg/kg; IP; daily; for 20 days) significantly reduces tumor size and weight in xenograft mouse models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Homozygous male BALB/c nude mice (CAnN.Cg-Foxn1 nu/Crl; 8-week-old) injected with COLO-205 cells[1]
Dosage: 10 mg/kg; 20 mg/kg
Administration: IP; daily; for 20 days
Result: Significantly reduced tumor size and weight.
Molecular Weight

504.59

Formula

C30H33FN2O4
SMILES

COC1=CC=CC(CCC2=CC=CC=C2OCC(O)CN3CCC(C4=NOC5=C4C=CC(F)=C5)CC3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GM-60186 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GM-60186GM60186GM 601865-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorHTR2B inhibitorcolorectal cancermigrationInhibitorinhibitorinhibit

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