2. GPCR/G Protein
  3. GnRH Receptor
  4. GPR10 agonist 1

GPR10 agonist 1 (compound 18-S4) is a potent GPR10 agonist with EC50 values of 80, 7.8 nM in the presence (10%) or absence (0%) of FBS, respectively. GPR10 agonist 1 has the potential for the research of chronic obesity.

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GPR10 agonist 1 Chemical Structure

GPR10 agonist 1 Chemical Structure

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GPR10 agonist 1 Related Antibodies

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Description

GPR10 agonist 1 (compound 18-S4) is a potent GPR10 agonist with EC50 values of 80, 7.8 nM in the presence (10%) or absence (0%) of FBS, respectively. GPR10 agonist 1 has the potential for the research of chronic obesity[1].

In Vivo

GPR10 agonist 1 (compound 18-S4) (0.5, 5 mg/kg; s.c.; daily for 12 day) decreases diet-induced obesity (DIO) mouse body weight[1].
Pharmacokinetic Parameters (1 mg/kg; s.c.; 7-9 weeks, male C57 mice)[1].

t1/2(h) Cmax(ng/mL) AUClast(ng·h/mL) AUC∞(ng·h/mL) AUC0-24 h(ng·h/mL)
7.81 1670 17700 17900 15500

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 24 weeks male mice (a diet-induced obesity (DIO) mouse model)[1]
Dosage: 0.5, 5 mg/kg
Administration: S.c.; daily for 12 daily
Result: Significantly decreased the body weight at 0.5 mg/kg and 5 mg/kg daily injection gave similar efficacy to the 0.5 mg/kg dose.
Molecular Weight

4517.20

Formula

C200H324N58O57S2
Sequence

Ser-Arg-Ala-His-Gln-Cys-Ser-{Nle}-Glu-Thr-Arg-Thr-Cys-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Thr-Gly-{hArg}-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2 (Disulfide bridge: Cys6-Cys13; multiple ethylene glycol-fatty acid; hArg=Homoarginine)
Sequence Shortening

SRAHQCS-{Nle}-ETRTCDINPAWYTG-{hArg}-GIRPVGRF-NH2 (Disulfide bridge: Cys6-Cys13; multiple ethylene glycol-fatty acid; hArg=Homoarginine)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GPR10 agonist 1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPR10 agonist 1GnRH ReceptorGonadotropin releasing hormone receptorGNRHRCHO-K1 cellschronic obesitydiabetesInhibitorinhibitorinhibit

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GPR10 agonist 1
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HY-P10378
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