GPR110 peptide agonist P12

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GPR110 peptide agonist P12 is a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 can be used in the study of developmental disorders and cancers related to GPR110.

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GPR110 peptide agonist P12 Chemical Structure

CAS No. : 1778685-49-6

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Description	GPR110 peptide agonist P12 is a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 can be used in the study of developmental disorders and cancers related to GPR110^[1].
Molecular Weight	1325.57
Formula	C₆₃H₉₆N₁₂O₁₇S
CAS No.	1778685-49-6
Sequence	Thr-Ser-Phe-Ser-Ile-Leu-Met-Ser-Pro-Phe-Val-Pro
Sequence Shortening	TSFSILMSPFVP
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (258 KB) Handling Instructions (2659 KB)
References	[1]. Stoveken H M, et al. Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist[J]. Proceedings of the National Academy of Sciences, 2015, 112(19): 6194-6199. [Content Brief]