1. GPCR/G Protein
  2. EBI2/GPR183
  3. GPR183-IN-1

GPR183-IN-1 (compound 15) is a potent and orally activity GPR183 inhibitor. GPR183-IN-1 inhibits Ca2+ mobilization with an IC50 value of 39.97 nM. GPR183-IN-1 has the potential for the research of cancer, autoimmune diseases, pain, and osteoporosis.

For research use only. We do not sell to patients.

GPR183-IN-1 Chemical Structure

GPR183-IN-1 Chemical Structure

CAS No. : 2924063-70-5

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Description

GPR183-IN-1 (compound 15) is a potent and orally activity GPR183 inhibitor. GPR183-IN-1 inhibits Ca2+ mobilization with an IC50 value of 39.97 nM. GPR183-IN-1 has the potential for the research of cancer, autoimmune diseases, pain, and osteoporosis[1].

In Vivo

Pharmacokinetic Parameters[1].

Parameters CL (mL/min/kg) T1/2 (h) Cmax (ng/mL) AUC0-t (ng·h/mL) Vss (L/kg) F (%)
IV 1 mg/kg 32.56 0.69 934.25 513.00 1.53 -
PO 10 mg/kg - 1.25 3026.21 6819.57 - 133.21

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

351.24

Formula

C16H19BrN2O2

CAS No.
SMILES

O=C(N1CCN(CC1)C2COC2)/C=C/C3=CC=C(C=C3)Br

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GPR183-IN-1
Cat. No.:
HY-163795
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