1. GPCR/G Protein Neuronal Signaling
  2. Neurokinin Receptor
  3. GR 64349

GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

GR 64349 Chemical Structure

GR 64349 Chemical Structure

CAS No. : 137593-52-3

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Based on 1 publication(s) in Google Scholar

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Description

GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively[1][2].

Molecular Weight

921.11

Formula

C42H68N10O11S

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Lys-Asp-Ser-Phe-Val-{Aaa}-Leu-Met-NH2

Sequence Shortening

KDSFV{Aaa}LM-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (54.28 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0856 mL 5.4282 mL 10.8565 mL
5 mM 0.2171 mL 1.0856 mL 2.1713 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0856 mL 5.4282 mL 10.8565 mL 27.1412 mL
5 mM 0.2171 mL 1.0856 mL 2.1713 mL 5.4282 mL
10 mM 0.1086 mL 0.5428 mL 1.0856 mL 2.7141 mL
15 mM 0.0724 mL 0.3619 mL 0.7238 mL 1.8094 mL
20 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.3571 mL
25 mM 0.0434 mL 0.2171 mL 0.4343 mL 1.0856 mL
30 mM 0.0362 mL 0.1809 mL 0.3619 mL 0.9047 mL
40 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.6785 mL
50 mM 0.0217 mL 0.1086 mL 0.2171 mL 0.5428 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
GR 64349
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HY-P1278
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