GW 848687X

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GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain.

For research use only. We do not sell to patients.

GW 848687X Chemical Structure

CAS No. : 612831-24-0

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Description

In Vivo

GW 848687X (30 mg/kg; po; b.i.d, 5 d) exhibits antihyperalgesic activity in an FCA-induced inflammatory joint pain model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	FCA induced joint pain model of inflammatory pain^[1]
Dosage:	30mg/kg
Administration:	po; twice daily for 5 days
Result:	Completely reversed pain sensation in rats and had anti-pain effects.

Molecular Weight

441.85

Formula

C₂₄H₁₈ClF₂NO₃

CAS No.

612831-24-0

SMILES

O=C(C1=CC=CC(C2=C(CCC2)C3=C(OCC4=CC=C(C=C4F)F)C=CC(Cl)=C3)=N1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Giblin GM, et al. The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain. Bioorg Med Chem Lett. 2007 Jan 15;17(2):385-9. [Content Brief]

GW 848687X Related Classifications

Endocrinology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW 848687X612831-24-0Prostaglandin ReceptorInhibitorinhibitorinhibit

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