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  6. H-Pro-Gly-Pro-OH

H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia.

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H-Pro-Gly-Pro-OH Chemical Structure

H-Pro-Gly-Pro-OH Chemical Structure

CAS No. : 7561-51-5

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Based on 1 publication(s) in Google Scholar

H-Pro-Gly-Pro-OH Related Antibodies

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Description

H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia[1][2].

In Vivo

H-Pro-Gly-Pro-OH (37.5 µg/kg; i.p.) activates the transcription of neurotrophins and their receptor genes after cerebral ischemia in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 270-320 g, male Wistar rats (focal cerebral ischemia)[2]
Dosage: 37.5 µg/kg
Administration: I.p.; 15, 1 h, 4, 8, 24, 28, 32, 48, 52, and 56 h
Result: Enhanced the transcription of Bdnf and TrkC 3 h after pMCAO and Ngf, TrkB, TrkC, and TrkA 24 h after pMCAO.
Molecular Weight

269.30

Formula

C12H19N3O4
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

H-Pro-Gly-Pro-OH
Sequence Shortening

PGP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (464.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7133 mL 18.5667 mL 37.1333 mL
5 mM 0.7427 mL 3.7133 mL 7.4267 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.7133 mL 18.5667 mL 37.1333 mL 92.8333 mL
5 mM 0.7427 mL 3.7133 mL 7.4267 mL 18.5667 mL
10 mM 0.3713 mL 1.8567 mL 3.7133 mL 9.2833 mL
15 mM 0.2476 mL 1.2378 mL 2.4756 mL 6.1889 mL
20 mM 0.1857 mL 0.9283 mL 1.8567 mL 4.6417 mL
25 mM 0.1485 mL 0.7427 mL 1.4853 mL 3.7133 mL
30 mM 0.1238 mL 0.6189 mL 1.2378 mL 3.0944 mL
40 mM 0.0928 mL 0.4642 mL 0.9283 mL 2.3208 mL
50 mM 0.0743 mL 0.3713 mL 0.7427 mL 1.8567 mL
60 mM 0.0619 mL 0.3094 mL 0.6189 mL 1.5472 mL
80 mM 0.0464 mL 0.2321 mL 0.4642 mL 1.1604 mL
100 mM 0.0371 mL 0.1857 mL 0.3713 mL 0.9283 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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H-Pro-Gly-Pro-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-Pro-Gly-Pro-OH7561-51-5Othersneutrophil chemoattractanttripeptideneurotrophinsInhibitorinhibitorinhibit

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