2. Membrane Transporter/Ion Channel Neuronal Signaling Cell Cycle/DNA Damage Anti-infection TGF-beta/Smad Stem Cell/Wnt
  3. Calcium Channel DNA/RNA Synthesis Parasite Sodium Channel TGF-beta/Smad
  4. Halofuginone hydrochloride (Standard)

Halofuginone hydrochloride (Standard) 

Cat. No.: HY-N1584BR Purity: ≥98%
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Halofuginone (hydrochloride) (Standard) is the analytical standard of Halofuginone (hydrochloride). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[4].

For research use only. We do not sell to patients.

Halofuginone hydrochloride (Standard) Chemical Structure

Halofuginone hydrochloride (Standard) Chemical Structure

CAS No. : 1217623-74-9

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Description

Halofuginone (hydrochloride) (Standard) is the analytical standard of Halofuginone (hydrochloride). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[4].

Molecular Weight

451.14

Formula

C16H18BrCl2N3O3
CAS No.
SMILES

O=C1C2=CC(Cl)=C(Br)C=C2N=CN1CC(C[C@H]3[C@@H](CCCN3)O)=O.Cl
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Halofuginone hydrochloride (Standard) Related Classifications

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Keywords:

Halofuginone hydrochloride (Standard)1217623-74-9Calcium ChannelDNA/RNA SynthesisParasiteSodium ChannelTGF-beta/SmadCa2+ channelsCa channelsNa channelsNa+ channelsTransforming growth factor betatype-Icollagencollagen-1prolyl-tRNAosteoarthritisTGF-βInhibitorinhibitorinhibit

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