Hardwickiic acid (Synonyms: (-)-Hardwikiic acid)

Cat. No.: HY-N3990 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid shows insecticidal activity.

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Hardwickiic acid Chemical Structure

CAS No. : 1782-65-6

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1 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Hardwickiic acid

•Nat Commun. 2023 Jun 3;14(1):3224. [Abstract]

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Description

Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid shows insecticidal activity^[1]^[2].

Molecular Weight

316.43

Formula

C₂₀H₂₈O₃

CAS No.

1782-65-6

Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@](CCC=C2C(O)=O)([H])[C@](C)([C@H](C)CC1)CCC3=COC=C3

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥98.0%

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Data Sheet (270 KB) SDS (251 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10(3):1716-1728. [Content Brief]

[2]. Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53(6):575. [Content Brief]

Hardwickiic acid Related Classifications

Neurological Disease Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hardwickiic acid1782-65-6(-)-Hardwikiic acidSodium ChannelNa channelsNa+ channelsHEK293chronic painvoltage-gated sodium channelsinsecticidal activityInhibitorinhibitorinhibit

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Hardwickiic acid (Synonyms: (-)-Hardwikiic acid)

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Hardwickiic acid Related Antibodies

1 Publications Citing Use of MCE Hardwickiic acid

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Hardwickiic acid Related Classifications

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The molarity calculator equation

The dilution calculator equation

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