hCA/VEGFR-2-IN-5

Cat. No.: HY-163710: FAQs
Data Sheet Handling Instructions

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hCA/VEGFR-2 IN-5 (compound 9) is an indolone-phenylsulfonamide and a potential dual inhibitor of cancer-related hCA IX/XII and VEGFR-2. The IC₅₀ values of hCA/VEGFR-2-IN-5 for VEGFR-2, hCA IX and hCA XII are 0.38 μM, 40 and 3.2 nM, respectively. hCA/VEGFR-2-IN-5 has antitumor activity.

For research use only. We do not sell to patients.

hCA/VEGFR-2-IN-5 Chemical Structure

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CA CA I CA Ⅱ CA Ⅸ CA XII

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

VEGFR-2

0.38 μM (IC₅₀)

hCA IX

40 nM (IC₅₀)

hCA XII

3.2 nM (IC₅₀)

In Vitro

hCA/VEGFR-2-IN-5 in HepG-2 and MCF-7 cells with IC₅₀values of 8.39~16.90 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

594.63

Formula

C₂₆H₃₄N₄O₁₀S

SMILES

O=S(C1=CC=C(N2N=NC(CO[C@H]3[C@@H]([C@H]([C@@H](CO3)OC(C)=O)OC(C)=O)OC(C)=O)=C2)C=C1)(NC4CCCCC4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Abbas HS, et al. New sulfonamide-based glycosides incorporated 1,2,3-triazole as cytotoxic agents through VEGFR-2 and carbonic anhydrase inhibitory activity. Sci Rep. 2024 Jun 6;14(1):13028. [Content Brief]

hCA/VEGFR-2-IN-5 Related Classifications

Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCA/VEGFR-2-IN-5VEGFRCarbonic AnhydraseVascular endothelial growth factor receptorCarbonate dehydrataseVEGFR-2HepG-2MCF-7antitumorInhibitorinhibitorinhibit

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