2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. hCAI/II-IN-3

hCAI/II-IN-3 (compound 5b) is a potent dual hCA I/II inhibitor with Ki values of 51.25, 13.15 and 42.18 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-3 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity.

For research use only. We do not sell to patients.

hCAI/II-IN-3 Chemical Structure

hCAI/II-IN-3 Chemical Structure

CAS No. : 2480283-93-8

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hCAI/II-IN-3 Related Antibodies

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Description

hCAI/II-IN-3 (compound 5b) is a potent dual hCA I/II inhibitor with Ki values of 51.25, 13.15 and 42.18 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-3 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity[1].

In Vitro

hCAI/II-IN-3 (compound 5b) (5-200 μM, 48 hours; HEK293T cells) has no obvious toxicity at HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

hCAI/II-IN-3 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Embryonic kidney (HEK293T) cells
Concentration: 5, 25, 50, 100 and 200 μM
Incubation Time: 48 hours
Result: Had no apparent cytotoxicity.
Molecular Weight

394.47

Formula

C16H18N4O4S2
CAS No.
SMILES

O=C(C1=CSC(NC(C2=CC=C(S(=O)(N)=O)C=C2)=O)=N1)NC3CCCC3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hCAI/II-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAI/II-IN-32480283-93-8Carbonic AnhydraseCarbonate dehydrataseanti-hypoxiccarbonic anhydrasedual hCA I/II inhibitorInhibitorinhibitorinhibit

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