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  4. hCAI/II-IN-9

hCAI/II-IN-9 is a carbonic anhydrase inhibitor with inhibitory activity against human carbonic anhydrase isoforms I, II, IX, and XII. The inhibition constants (Ki) of hCAI/II-IN-9 for hCA I are in the range of 7.9-894 nM, for hCA II are in the range of 7.5-1645 nM, for hCA IX are in the range of 5.0-240 nM, and for hCA XII are in the range of 0.47-2.83 nM. hCAI/II-IN-9 may have potential applications in inhibiting a variety of pathologies involving these carbonic anhydrase isoforms.

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hCAI/II-IN-9 Chemical Structure

hCAI/II-IN-9 Chemical Structure

CAS No. : 175014-68-3

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Description

hCAI/II-IN-9 is a carbonic anhydrase inhibitor with inhibitory activity against human carbonic anhydrase isoforms I, II, IX, and XII. The inhibition constants (Ki) of hCAI/II-IN-9 for hCA I are in the range of 7.9-894 nM, for hCA II are in the range of 7.5-1645 nM, for hCA IX are in the range of 5.0-240 nM, and for hCA XII are in the range of 0.47-2.83 nM. hCAI/II-IN-9 may have potential applications in inhibiting a variety of pathologies involving these carbonic anhydrase isoforms[1].

Molecular Weight

336.32

Formula

C13H12N4O5S
CAS No.
SMILES

O=S(C1=CC=C(NC(NC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)(N)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hCAI/II-IN-9 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAI/II-IN-9175014-68-3OthersInhibitorinhibitorinhibit

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