hCAIX/XII-IN-1

Cat. No.: HY-146988: FAQs
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hCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the K_I values of 0.48 µM and 0.83 µM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells.

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hCAIX/XII-IN-1 Chemical Structure

CAS No. : 3033040-76-2

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CA CA I CA Ⅱ CA Ⅸ CA XII

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

CA Ⅸ

In Vitro

hCAIX/XII-IN-1 (compound 11a) (3.125, 6.25, 12.5, 25, 50 µM, 48 h) shows antiproliferative activity with an IC₅₀ value of 0.48 µM in MCF-7 cells^[1].
hCAIX/XII-IN-1 (0.48 µM; 24 h) increases the cell populations of Sub-G1 phase^[1].
hCAIX/XII-IN-1 (0.48 µM) induces apoptosis in MCF-7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MCF-7 cells
Concentration:	3.125, 6.25, 12.5, 25, 50 µM
Incubation Time:	48 h
Result:	Showed antiproliferative activity with an IC₅₀ value of 0.48 µM in MCF-7 cells.

Cell Cycle Analysis^[1]

Cell Line:	MCF-7 cells
Concentration:	0.48 µM
Incubation Time:	24 h
Result:	Significantly increased the cell populations of Sub-G1 phase.

Apoptosis Analysis^[1]

Cell Line:	MCF-7 cells
Concentration:	0.48 µM
Incubation Time:
Result:	Induced apoptosis in MCF-7 cells.

Molecular Weight

397.42

Formula

C₁₉H₁₁NO₅S₂

CAS No.

3033040-76-2

SMILES

O=C(C1=CC2=C(OC1=O)C=CC=C2)CN3C(S/C(C3=O)=C\C4=CC=CS4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Eldehna WM, et al. Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. J Enzyme Inhib Med Chem. 2022; 37(1):531-541.

hCAIX/XII-IN-1 Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX/XII-IN-13033040-76-2Carbonic AnhydraseApoptosisCarbonate dehydrataseMCF-7 cellsapoptosisantiproliferativeSub-G1 phasecarbonic anhydraseInhibitorinhibitorinhibit

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