HCV-IN-34

Cat. No.: HY-144107: FAQs
Data Sheet Handling Instructions

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HCV-IN-34 (compound 3i) is an orally active and potent HCV entry inhibitor. HCV-IN-35 shows excellent antiviral activity, with an EC₅₀ of 0.010 μM and a CC₅₀ (half-maximal cytotoxic concentration) of 8.23 μM.

For research use only. We do not sell to patients.

HCV-IN-34 Chemical Structure

CAS No. : 2425805-22-5

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

EC₅₀: 0.010 ± 0.003 μM (HCV)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7.5	CC₅₀	3.72 μM Compound: 3i	Cytotoxicity against human Huh7.5 cells infected with HCVcc assessed as reduction in cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human Huh7.5 cells infected with HCVcc assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 35050619]
Huh-7.5	CC₅₀	5.22 μM Compound: 3i	Cytotoxicity against human Huh7.5 cells carrying HCV subgenomic replicons assessed as reduction in cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human Huh7.5 cells carrying HCV subgenomic replicons assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 35050619]
Huh-7.5	CC₅₀	7.34 μM Compound: 3i	Cytotoxicity against human Huh7.5 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human Huh7.5 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 35050619]

Molecular Weight

514.10

Formula

C₃₁H₃₆ClN₅

CAS No.

2425805-22-5

SMILES

N#CC1=CC=C(N2CCN(C)CCC2)C=C1CN3CCN(C(C4=CC=C(Cl)C=C4)C5=CC=CC=C5)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang Y, Li J, Tan J, Yang B, Quan Y, Peng Z, Li Y, Li Z. Design, Synthesis, and Biological Evaluation of 2-((4-Bisarylmethyl-piperazin-1-yl)methyl)benzonitrile Derivatives as HCV Entry Inhibitors. J Med Chem. 2022 Feb 10;65(3):2107-2121. [Content Brief]

HCV-IN-34 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HCV-IN-342425805-22-5HCVHepatitis C virusHuh7.5 cellshepatitis C virus (HCV)antiviral activityorally activeInhibitorinhibitorinhibit

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