HDAC-IN-41 

HDAC-IN-41 (Compound 7c) is a selective, orally active class I HDAC inhibitor with IC₅₀ values of 0.62, 1.46 and 0.62 μM against HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-41 shows NO releasing activity^[1].

HDAC-IN-41 (Compound 7c) shows anti-proliferative activity with IC₅₀ values of 0.32 ± 0.06, 0.59 ± 0.09, 0.54 ± 0.05, 1.23 ± 0.06, 2.69 ± 0.15, 0.93 ± 0.08 and 1.03 ± 0.09 μM against HEL, MOLT-4, Jurkat, HeLa, PC-3, HCT116 and A549 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-41 (Compound 7c) (30 mg/kg/d; p.o., 15 days) inhibits tumor growth in a HCT116 xenograft model in nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

446.48

C₂₀H₂₂N₄O₆S

2490309-83-4

O=S(C1=[N+]([O-])ON=C1OCCCCCC(NC2=C(N)C=CC=C2)=O)(C3=CC=CC=C3)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ding Q, et al. Synthesis and biological study of class I selective HDAC inhibitors with NO releasing activity. Bioorg Chem. 2020 Nov;104:104235.  [Content Brief]