HDAC-IN-67 

HDAC-IN-67 (compound 27f) is an HDAC inhibitor against HDAC1 and HDAC6, with IC₅₀ values of 22 nM and 8 nM, respectively. HDAC-IN-67 inhibits cell proliferation and induces cell apoptosis. HDAC-IN-67 exhibits antitumor activity^[1].

HDAC-IN-67 exhibits antiproliferative activity in tumour cells K562, MV4-11, HEL, SU-DHL-2 and WSU-DLCL-2, with IC₅₀ values of 4.42 μM, 0.79 μM, 2.43 μM, 1.05 μM, 1.43 μM, respectively^[1].
HDAC-IN-67 induces WSU-DLCL-2 cells apoptosis (10 μM: 91.57%; 5 μM: 77.05%)^[1].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-67 (i.v.:50 mg/kg) reveals a clearance (CL) of 65.1 ml/(h·kg) and a half-life (T_1/2) of 0.361 h after i.v.^[1].
HDAC-IN-67 (p.o.:10 mg/kg) exhibits low oral bioavailability(F=3.15%)^[1].
HDAC-IN-67 (i.p.:50mg/kg once daily for 21 days) demonstrates a moderate in vivo antitumor potency with TGI of 31.5%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

525.73

C₃₀H₄₇N₅O₃

2821923-75-3

ONC(CCCCCCC(N1CCN(CC1)CC([C@@H]2CC[C@](C=C)(C)[C@H](C(CN3N=CC=C3)=C)C2)=C)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gao Y,et al., Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β-elemene scaffold. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2195991.  [Content Brief]