2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC-IN-71

HDAC-IN-71 (Compound 17q) is a potent HDAC inhibitor with IC50 values of 12.6, 14.1, 20, 3, and 72 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC10, respectively. HDAC-IN-71 induces apoptosis and can be used in cancer research.

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HDAC-IN-71 Chemical Structure

HDAC-IN-71 Chemical Structure

CAS No. : 2995354-52-2

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HDAC-IN-71 Related Antibodies

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Description

HDAC-IN-71 (Compound 17q) is a potent HDAC inhibitor with IC50 values of 12.6, 14.1, 20, 3, and 72 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC10, respectively. HDAC-IN-71 induces apoptosis and can be used in cancer research[1].

IC50 & Target

HDAC1

12.6 nM (IC50)

HDAC2

14.1 nM (IC50)

HDAC3

20 nM (IC50)

HDAC6

3 nM (IC50)

HDAC10

72 nM (IC50)

In Vitro

HDAC-IN-71 (0-1.6 μM; 24 h) inhibits colony formation in a dose-dependent manner and completely inhibits colony formation of DU145 cells at a concentration of 3.2 μM[1].
HDAC-IN-71 (0-1.6 μM; 72 h) arrests cells in G2/M phase and induces apoptosis in DU145 cell line in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-71 Related Antibodies

Cell Migration Assay [1]

Cell Line: DU145 cells
Concentration: 0, 0.2, 0.4, 0.8, 1.6 μM
Incubation Time: 12 h
Result: Inhibited cancer cell migration.

Cell Cycle Analysis[1]

Cell Line: DU145 cells
Concentration: 0, 0.2, 0.4, 0.8, 1.6 μM
Incubation Time: 72 h
Result: Arrested cells in G2/M phase in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: DU145 cells
Concentration: 0.8, 1.6, 3.2 μM
Incubation Time: 24 h
Result: Induced histone acetylation and inhibited HDAC6 expression.
In Vivo

HDAC-IN-71 (100, 200 mg/kg; p.o.; daily; 40 days) inhibits tumor growth at concentrations of 100 mg/kg and 200 mg/kg, with TGI values of 50.92% and 68.00% respectively[1].
Pharmacokinetic analysis[1]

Parameters I.V. (2 mg/kg) P.O. (10 mg/kg)
AUC0-∞ (h ng/mL) 1633.35 3799.46
T1/2 (h) 3.12 2.87
CL (L/h/kg) 1.57
V (L/kg) 4.63
Cmax(ng/mL) 851.5 774.0
F 46.52%

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice[1]
Dosage: 100, 200 mg/kg
Administration: Oral administration; daily; 40 days
Result: Significantly inhibited prostate cancer (PCa) tumor growth.
Molecular Weight

360.40

Formula

C19H24N2O5
CAS No.
SMILES

COC1=C(C=CC=C1)/C=C2CC(N(C\2=O)CCCCCCC(NO)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC-IN-71 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-712995354-52-2HDACApoptosisHistone deacetylasesProstate cancerItaconimideAntiproliferativeInhibitorinhibitorinhibit

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