2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-15

HDAC6-IN-15 is a selective histone deacetylase 6 (HDAC6) inhibitor. HDAC6-IN-15 has potent inhibitory activity for HDAC6 with IC50 value of 38.2 nM. HDAC6-IN-15 can be used for the research of cancer and neurodegenerative diseases.

For research use only. We do not sell to patients.

HDAC6-IN-15 Chemical Structure

HDAC6-IN-15 Chemical Structure

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HDAC6-IN-15 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC6-IN-15 is a selective histone deacetylase 6 (HDAC6) inhibitor. HDAC6-IN-15 has potent inhibitory activity for HDAC6 with IC50 value of 38.2 nM. HDAC6-IN-15 can be used for the research of cancer and neurodegenerative diseases[1].

IC50 & Target

HDAC6

38.2 nM (IC50)

In Vitro

HDAC6-IN-15 (Compound II-5) has potent inhibitory activity for HDAC6 with IC50 value of 38.2 nM[1].
HDAC6-IN-15 (50 μL; 48 h) has antitumor activity against 22RV1, MM1.S, MV4-11, JEKO-1 and 4T1 cells with IC50 value of 8.90 μM, 11.90 μM, 7.83 μM, 4.80 μM and 16.51 μM, respectively[1].
HDAC6-IN-15 (100, 200, 400, 800 nM; 24 h) dose-dependently induces accumulation of acetylated a-tubulin[1].
HDAC6-IN-15 (5, 10 μM; 24 h) can induce cellular apoptosis[1].
HDAC6-IN-15 (4 mg/mL; 48 h) demonstrates an optimal profile on human plasma stability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-15 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: 22RV1, MM1.S, MV4-11, JEKO-1 and 4T1 cells
Concentration: 50 μL
Incubation Time: 48 h
Result: Showed moderate anti-proliferative activities in all the cancer cell lines.

Western Blot Analysis[1]

Cell Line: JEKO-1 cells; 4T1 cells
Concentration: 100, 200, 400, 800 nM; 5, 10 μM
Incubation Time: 24 h
Result: Significantly increase the levels of acetylated α-tubulin in a concentration dependent manner.
Slightly increased the levels of histone H3 and H4 acetylation.
Significantly increased the ratio of acetylated α-tubulin at the concentration of 800 nM.
Dramatically increased the levels of cleavage of PARP and caspase-3 in cells dose-dependently.

Apoptosis Analysis[1]

Cell Line: 4T1 cells
Concentration: 5, 10 μM
Incubation Time: 24 h
Result: Triggered apoptosis in 4T1 cells in a dose-dependent manner, in particularly undergoing early stage apoptosis upon 18 h treatment.
Molecular Weight

477.35

Formula

C25H28FFeN3O2
SMILES

[][Fe][].FC(C=C(C(NO)=O)C=C1)=C1CN(CC2)CCN2C(CCc3cccc3)c4cccc4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC6-IN-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-15HDACHistone deacetylasesHistone deacetylase 6 (HDAC6)inhibitioncancerneurodegenerative diseasesInhibitorinhibitorinhibit

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