2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Dihydroorotate Dehydrogenase DNA/RNA Synthesis
  4. hDHODH-IN-12

hDHODH-IN-12 is a potent DHODH inhibitor with an IC50 value of 0.421 μM. DHODH is the rate-limiting enzyme in the de novo synthesis of pyrimidine which is essential in DNA/RNA Synthesis. hDHODH-IN-12 is present in the inner membrane of human mitochondria.hDHODH-IN-12 can be used for the research of lung cancer.

For research use only. We do not sell to patients.

hDHODH-IN-12 Chemical Structure

hDHODH-IN-12 Chemical Structure

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hDHODH-IN-12 Related Antibodies

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Description

hDHODH-IN-12 is a potent DHODH inhibitor with an IC50 value of 0.421 μM. DHODH is the rate-limiting enzyme in the de novo synthesis of pyrimidine which is essential in DNA/RNA Synthesis. hDHODH-IN-12 is present in the inner membrane of human mitochondria.hDHODH-IN-12 can be used for the research of lung cancer[1].

IC50 & Target

IC50: 0.421 μM (DHODH)[1]
In Vitro

hDHODH-IN-12 (compound 5c) (100 μM; 24 h) reduces cell viability in A549, H1299 and H1975 cell lines[1].
The TC50 of A549, H1299, and H1975 cells are 11, 11 and 15 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

hDHODH-IN-12 Related Antibodies

Cell Viability Assay[1]

Cell Line: A549, H1299, and H1975 cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Reduced cell viability by more than 50%.
Molecular Weight

440.37

Formula

C22H15F3N4O3
SMILES

O=C(C1=CNC2=C1C=C(NC3=CC=C([N+]([O-])=O)C=C3)C=C2)NC4=CC=CC(C(F)(F)F)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hDHODH-IN-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hDHODH-IN-12Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHDihydroorotateDehydrogenasepyrimidinebiosynthesisA549H1299H1975cancerInhibitorinhibitorinhibit

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