2. Metabolic Enzyme/Protease Apoptosis
  3. Dihydroorotate Dehydrogenase Ferroptosis
  4. hDHODH-IN-15

hDHODH-IN-15 (Compound H19) is an inhibitor for human dihydroguanylate dehydrogenase (hDHODH) with an IC50 of 0.21 µM. hDHODH-IN-15 exhibits cytotoxicity in cancer cells NCI-H226, HCT-116, and MDA-MB-231, with IC50 of 0.95-2.81 µM. hDHODH-IN-15 induces ferroptosis in HCT-116, and exhibits antitumor efficacy.

For research use only. We do not sell to patients.

hDHODH-IN-15 Chemical Structure

hDHODH-IN-15 Chemical Structure

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hDHODH-IN-15 Related Antibodies

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Description

hDHODH-IN-15 (Compound H19) is an inhibitor for human dihydroguanylate dehydrogenase (hDHODH) with an IC50 of 0.21 µM. hDHODH-IN-15 exhibits cytotoxicity in cancer cells NCI-H226, HCT-116, and MDA-MB-231, with IC50 of 0.95-2.81 µM. hDHODH-IN-15 induces ferroptosis in HCT-116, and exhibits antitumor efficacy[1].

Molecular Weight

338.36

Formula

C19H18N2O4
SMILES

C#CC(N1CCN(CC1)C(/C=C/C=C/C2=CC3=C(OCO3)C=C2)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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hDHODH-IN-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hDHODH-IN-15Dihydroorotate DehydrogenaseFerroptosisDHODHNCI-H226HCT-116MDA-MB-231piperineInhibitorinhibitorinhibit

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