hDHODH-IN-8

Cat. No.: HY-145261: FAQs
Data Sheet Handling Instructions

Molarity Calculator

hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC₅₀ of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and excellent aqueous solubility. hDHODH-IN-8 has the potential for the research of tumor disease, especially lymphoma.

For research use only. We do not sell to patients.

hDHODH-IN-8 Chemical Structure

CAS No. : 2757405-31-3

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Daudi	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human Daudi cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human Daudi cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
HEL	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human HEL cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human HEL cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
HL-60	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
L02	IC₅₀	517.8 nM Compound: 13t	Cytotoxicity against human L02 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Cytotoxicity against human L02 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
MV4-11	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
Raji	IC₅₀	7.7 nM Compound: 13t	Antiproliferative activity against human Raji cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human Raji cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
SUD4	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
SU-DHL-6	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
THP-1	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human THP-1 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human THP-1 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]

Molecular Weight

487.35

Formula

C₂₁H₁₅F₆N₃O₄

CAS No.

2757405-31-3

SMILES

FC1=C(NC(/C(C#N)=C(O)/C)=O)C=C(O[C@H](C(F)(F)F)C)C(C(NC2=C(F)C=CC=C2F)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li C, et al. Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment. J Med Chem. 2021;64(24):18175-18192. [Content Brief]

hDHODH-IN-8 Related Classifications

Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hDHODH-IN-82757405-31-3Dihydroorotate DehydrogenaseDHODHhuman dihydroorotate dehydrogenaseantiproliferativeaqueous solubilitylymphomaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks