HGPRT/TBrHGPRT1-IN-1 

HGPRT/TBrHGPRT1-IN-1 (Compound 5) is a selective inhibitor targeting human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Trypanosoma bruce HGPRT1 (TBrHGPRT1) (both K_i=3 nM). HGPRT/TBrHGPRT1-IN-1 ultimately results in decreased cell growth. HGPRT/TBrHGPRT1-IN-1 is primarily used in the research of infectious diseases and cancer^[1].

HGPRT/TBrHGPRT1-IN-1 inhibition activity is K_i=3 nM (human HGPRT); 10 nM (Pf HGXPRT); 60 nM (Pv HGPRT); 3 nM (TBr HGPRT1); 0.3 μM (Mtb HGPRT); 0.1 μM (Hp XGHPR); 4 μM (Ec XGPRT)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

494.33

C₁₅H₂₄N₆O₉P₂

NC1=NC2=C(C(N1)=O)N=CN2[C@@H]3C[C@H](N(C3)C(CCP(O)(O)=O)=O)COCCP(O)(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Cheshmazar N, et al. Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation. Future Med Chem. 2024 Apr 16.  [Content Brief]