2. NF-κB
  3. NF-κB
  4. HSR1304

HSR1304 (Compound 5d) is a potent inhibitor of NFκB. The multifunctional transcription factor, nuclear factor-κB (NF-κB), is broadly involved in multiple human diseases, such as cancer and chronic inflammation. HSR1304 has the potential for the research of cancer diseases.

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HSR1304 Chemical Structure

HSR1304 Chemical Structure

CAS No. : 2763363-08-0

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HSR1304 Related Antibodies

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

HSR1304 (Compound 5d) is a potent inhibitor of NFκB. The multifunctional transcription factor, nuclear factor-κB (NF-κB), is broadly involved in multiple human diseases, such as cancer and chronic inflammation. HSR1304 has the potential for the research of cancer diseases[1].

Cellular Effect
Cell Line Type Value Description References
ACHN GI50
1.977 μM
Compound: 5d
Anticancer activity against human ACNH cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
Anticancer activity against human ACNH cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
[PMID: 34500188]
HCT-15 GI50
1.739 μM
Compound: 5d
Anticancer activity against human HCT-15 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
Anticancer activity against human HCT-15 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
[PMID: 34500188]
MDA-MB-231 GI50
2.281 μM
Compound: 5d
Anticancer activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
Anticancer activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
[PMID: 34500188]
NCI-H23 GI50
1.938 μM
Compound: 5d
Anticancer activity against human NCI-H23 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
Anticancer activity against human NCI-H23 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
[PMID: 34500188]
NUGC-3 GI50
1.591 μM
Compound: 5d
Anticancer activity against human NUCC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
Anticancer activity against human NUCC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
[PMID: 34500188]
PC-3 GI50
2.008 μM
Compound: 5d
Anticancer activity against human PC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
Anticancer activity against human PC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
[PMID: 34500188]
Molecular Weight

420.89

Formula

C24H21ClN2O3
CAS No.
SMILES

COC1=CC=CC=C1NC(C2C3=CC=CC=C3CCN2C(C4=CC=C(C=C4)Cl)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HSR1304 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSR13042763363-08-0HSR 1304HSR-1304NF-κBNuclear factor-κBNuclear factor-kappaBNFκBcancerchronic inflammationInhibitorinhibitorinhibit

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