Hydralazine-d₄ hydrochloride 

Hydralazine-d4 hydrochloride is the deuterium labeled Hydralazine hydrochloride. Hydralazine hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

200.66

C₈H₅D₄ClN₄

2749234-32-8

304-20-1

N/N=C1C2=C(C([2H])=C([2H])C([2H])=C2[2H])C=NN/1.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Bourreli, B., et al., Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion. Can J Anaesth, 1988. 35(3 ( Pt 1)): p. 242-8.  [Content Brief]

  [3]. Kandler, M.R., et al., Hydralazine for essential hypertension. Cochrane Database Syst Rev, 2010(8): p. CD004934.  [Content Brief]