2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. ICI 169369 free base

ICI 169369 (free base) is an orally active, selective and non-competitive antagonist against 5HT receptor. ICI 169369 (free base) blunts the vasopressin (AVP), but not the ACTH, prolactin or growth hormone reponses to insulin-induced hypoglycaemia. ICI 169369 (free base) blocks centrally mediated 5-HT responses and lowers portal pressure in portal hypertensive rats.

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ICI 169369 free base Chemical Structure

ICI 169369 free base Chemical Structure

CAS No. : 85273-95-6

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ICI 169369 free base Related Antibodies

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Description

ICI 169369 (free base) is an orally active, selective and non-competitive antagonist against 5HT receptor. ICI 169369 (free base) blunts the vasopressin (AVP), but not the ACTH, prolactin or growth hormone reponses to insulin-induced hypoglycaemia. ICI 169369 (free base) blocks centrally mediated 5-HT responses and lowers portal pressure in portal hypertensive rats[1][2][3][4].

Molecular Weight

308.44

Formula

C19H20N2S
CAS No.
SMILES

CN(C)CCSC1=NC2=CC=CC=C2C=C1C3=CC=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ICI 169369 free base Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICI 16936985273-95-6ICI169369ICI-1693695-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptororally active5HT2 receptorAVP5-HT responsesportal hypertensiveInhibitorinhibitorinhibit

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