2. Epigenetics
  3. Epigenetic Reader Domain
  4. iHAC

iHAC is an inhibitor HSP90-anchoring chimera, that covalently binds BRD4 ligand (+)-JQ-1 to HSP90, and inhibits the proliferation of cancer cells. iHAC activates the anti-tumor immune response, inhibits the recurrence and metastasis of 4T1 breast cancer in mouse models.

For research use only. We do not sell to patients.

iHAC Chemical Structure

iHAC Chemical Structure

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iHAC Related Antibodies

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Description

iHAC is an inhibitor HSP90-anchoring chimera, that covalently binds BRD4 ligand (+)-JQ-1 to HSP90, and inhibits the proliferation of cancer cells. iHAC activates the anti-tumor immune response, inhibits the recurrence and metastasis of 4T1 breast cancer in mouse models[1].

Molecular Weight

1241.56

Formula

C50H46ClIN16O7S3
SMILES

ClC1=CC=C(C2=N[C@@H](CC(NCC3=CN(CCCC(N(CC#N)S(=O)(C4=CC=C(C(NCCCN5C(SC6=CC(OCO7)=C7C=C6I)=NC8=C(N)N=CN=C85)=O)C=C4)=O)=O)N=N3)=O)C9=NN=C(C)N9C%10=C2C(C)=C(C)S%10)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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iHAC Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iHACEpigenetic Reader DomainMDA-MB-2314T1NSG mouseInhibitorinhibitorinhibit

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iHAC
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HY-170453
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