1. Metabolic Enzyme/Protease
  2. Glycosidase
  3. IHVR-17028

IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC50 of 0.24 μM. IHVR-17028 can be used for infectious diseases research.

For research use only. We do not sell to patients.

IHVR-17028 Chemical Structure

IHVR-17028 Chemical Structure

CAS No. : 1428247-78-2

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Description

IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC50 of 0.24 μM. IHVR-17028 can be used for infectious diseases research[1][2].

Cellular Effect
Cell Line Type Value Description References
Huh-7 EC50
0.2 μM
Compound: 3
Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis
Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis
[PMID: 23747225]
Huh-7 CC50
500 μM
Compound: 3
Cytotoxicity against human Huh7.5 cells by MTT assay
Cytotoxicity against human Huh7.5 cells by MTT assay
[PMID: 23747225]
Huh-7 CC50
500 μM
Compound: 24
Cytotoxicity against human Huh7.5 cells by MTT assay
Cytotoxicity against human Huh7.5 cells by MTT assay
[PMID: 23453839]
In Vitro

In virus yield reduction assays, IHVR-17028 inhibits viral activities with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM for bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), DENV (serotype 2, New Guinea C), respectively. And in MTT assays, IHVR-17028 exhibits IC50 values of all >500 μM in MDBK, Huh7.5 or BHK cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In Pharmacokinetic analysis in rats, IHVR17028 (oral gavage; 75 mg/kg) shows a Cmax value of 0.18 μg/ml; the Tmax value is 1.56 hours; and the F% value is 12% after PO administration, the T1/2 value is 0.88 hour after iv. adminstration[1].
IHVR-17028 (oral gavage; 25-50 mg/kg; treatment 1 day prior to virus challenging) exhibits significant protection in mouse model of lethal MARV infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice are challenged with 1,000 PFU mouse adapted MARV via IP injection[1]
Dosage: 50 mg/kg
Administration: Treatment 1 day prior to virus challenging
Result: Exhibited protection in mouse when the treatment is initiated 1 day prior to virus challenging.
Animal Model: C57B1/6 mice challenged with 1,000 PFU mouse adapted EBOV[1]
Dosage: 25 mg/kg
Administration: Twice daily at 12 h interval; starting 4 h post infection for 10 days
Result: Inhibited EBOV infection in mice.
Molecular Weight

428.61

Formula

C23H44N2O5

CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCN(C(C(C)(C)C)=O)C2CCCCC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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IHVR-17028 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
IHVR-17028
Cat. No.:
HY-139663
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