IHVR-17028

Name: IHVR-17028
Brand: MedChemExpress
SKU: HY-139663
Rating: 4.5 (1 reviews)

Cat. No.: HY-139663 Purity: 99.61%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC₅₀ values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC₅₀ of 0.24 μM. IHVR-17028 can be used for infectious diseases research.

For research use only. We do not sell to patients.

IHVR-17028 Chemical Structure

CAS No. : 1428247-78-2

Size	Price	Stock	Quantity
1 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 830	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1760	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2200	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2750	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	EC₅₀	0.2 μM Compound: 3	Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis	[PMID: 23747225]
Huh-7	CC₅₀	500 μM Compound: 3	Cytotoxicity against human Huh7.5 cells by MTT assay Cytotoxicity against human Huh7.5 cells by MTT assay	[PMID: 23747225]
Huh-7	CC₅₀	500 μM Compound: 24	Cytotoxicity against human Huh7.5 cells by MTT assay Cytotoxicity against human Huh7.5 cells by MTT assay	[PMID: 23453839]

In Vitro

In virus yield reduction assays, IHVR-17028 inhibits viral activities with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM for bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), DENV (serotype 2, New Guinea C), respectively. And in MTT assays, IHVR-17028 exhibits IC₅₀ values of all >500 μM in?MDBK, Huh7.5 or BHK cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In Pharmacokinetic analysis in rats, IHVR17028 (oral gavage; 75 mg/kg) shows a C_max?value of 0.18 μg/ml; the Tmax value is 1.56 hours; and the F% value is 12% after PO administration, the T_1/2 value is 0.88 hour after iv. adminstration^[1].
IHVR-17028 (oral gavage; 25-50 mg/kg; treatment 1 day prior to virus challenging) exhibits significant protection in mouse model of lethal MARV infection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c mice are challenged with 1,000 PFU mouse adapted MARV via IP injection^[1]
Dosage:	50 mg/kg
Administration:	Treatment 1 day prior to virus challenging
Result:	Exhibited protection in mouse when the treatment is initiated 1 day prior to virus challenging.

Animal Model:	C57B1/6 mice challenged with 1,000 PFU mouse adapted EBOV^[1]
Dosage:	25 mg/kg
Administration:	Twice daily at 12 h interval; starting 4 h post infection for 10 days
Result:	Inhibited EBOV infection in mice.

Molecular Weight

428.61

Formula

C₂₃H₄₄N₂O₅

CAS No.

1428247-78-2

Appearance

Oil

Color

Colorless to light yellow

SMILES

OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCN(C(C(C)(C)C)=O)C2CCCCC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (233.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3331 mL	11.6656 mL	23.3312 mL
5 mM	0.4666 mL	2.3331 mL	4.6662 mL
10 mM	0.2333 mL	1.1666 mL	2.3331 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (11.67 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (11.67 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (11.67 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.61%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (247 KB) HNMR (163 KB) RP-HPLC (250 KB) LCMS (109 KB)

Handling Instructions (2659 KB)

References

[1]. Jinhong Chang, et al. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.Antiviral Res. 2013 Jun;98(3):432-40. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3331 mL	11.6656 mL	23.3312 mL	58.3281 mL
	5 mM	0.4666 mL	2.3331 mL	4.6662 mL	11.6656 mL
	10 mM	0.2333 mL	1.1666 mL	2.3331 mL	5.8328 mL
	15 mM	0.1555 mL	0.7777 mL	1.5554 mL	3.8885 mL
	20 mM	0.1167 mL	0.5833 mL	1.1666 mL	2.9164 mL
	25 mM	0.0933 mL	0.4666 mL	0.9332 mL	2.3331 mL
	30 mM	0.0778 mL	0.3889 mL	0.7777 mL	1.9443 mL
	40 mM	0.0583 mL	0.2916 mL	0.5833 mL	1.4582 mL
	50 mM	0.0467 mL	0.2333 mL	0.4666 mL	1.1666 mL
	60 mM	0.0389 mL	0.1944 mL	0.3889 mL	0.9721 mL
	80 mM	0.0292 mL	0.1458 mL	0.2916 mL	0.7291 mL
	100 mM	0.0233 mL	0.1167 mL	0.2333 mL	0.5833 mL

IHVR-17028 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IHVR-170281428247-78-2IHVR17028IHVR 17028Glucosidaseviraltacaribe virusDENVBVDVdiarrhea virusMDBKHuh7.5BHKInhibitorinhibitorinhibit

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IHVR-17028

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Complete Stock Solution Preparation Table

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