Influenza A virus-IN-15 

Influenza A virus-IN-15 (Compound 9b), a quinoline derivative, is a broad-spectrum inhibitor of influenza A viruses with acceptable cytotoxicity (IC₅₀: 0.88-6.33 μM). Influenza A virus-IN-15 can inhibit the transcription and replication of viral RNA and is used in research for its antiviral effects against influenza A viruses (IAV)^[1].

IC50: 0.88 μM (IAV)^[1].

Influenza A virus-IN-15 (Compound 9b) can inhibit the activity of IAV with an IC₅₀ value of 0.88 μM^[1].
Influenza A virus-IN-15 effectively inhibits the infection of A/Puerto Rico/8/34(H1N1), A/Aichi/2/1968(X31)(H3N2), B/Brisbane/60/2008(B/Victoria), and B/Phuket/3073/2013(B/Yamagata) strains in a dose-independent manner, with IC⁵⁰ values of 3.57 μM, 4.66 μM, 5.16 μM, and 6.33 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

510.59

C₂₉H₃₀N₆O₃

O=C(CN1CCN(C2=NC(C(OCC(NCC3=CC=CC=C3)=O)=CC=C4)=C4C=C2)CC1)NC5=NC=CC=C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li H, Zhao J, et al. Synthesis and biological evaluation of substituted quinolines containing piperazine moieties against Influenza A virus[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 130081.  [Content Brief]