2. Immunology/Inflammation
  3. NO Synthase
  4. iNOs-IN-3

iNOs-IN-3 (Compound 2d) is an orally active nitric oxide synthase (iNOS) inhibitor (IC50=3.342 µM). iNOs-IN-3 shows anti-inflammatory activity and can be used in LPS-induced acute lung injury (ALI) research.

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iNOs-IN-3 Chemical Structure

iNOs-IN-3 Chemical Structure

CAS No. : 2241674-94-0

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iNOs-IN-3 Related Antibodies

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Description

iNOs-IN-3 (Compound 2d) is an orally active nitric oxide synthase (iNOS) inhibitor (IC50=3.342 µM). iNOs-IN-3 shows anti-inflammatory activity and can be used in LPS-induced acute lung injury (ALI) research[1].

IC50 & Target

IC50: 3.342 µM (iNOS)[1]
Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
3.342 μM
Compound: 2d
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide synthase production measured after 24 hrs by ELISA
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide synthase production measured after 24 hrs by ELISA
[PMID: 33065432]
In Vitro

iNOs-IN-3 (25 μM; 24 h) inhibits LPS-induced RAW 264.7 cells[1].
iNOs-IN-3 (12.5 μM; 24 h) can decrease the expression of iNOS[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

iNOs-IN-3 Related Antibodies

Cell Viability Assay[1]

Cell Line: RAW 264.7 microphages
Concentration: 25 μM
Incubation Time: 24 hours
Result: Showed higher inhibitory activity (IC50=14.72 µM) in LPS-induced RAW 264.7 cells.

Cell Viability Assay[1]

Cell Line: RAW 264.7 microphages
Concentration: 12.5 μM
Incubation Time: 24 hours
Result: Inhibited the LPS-induced mRNA expression of iNOS obviously.

Cell Viability Assay[1]

Cell Line: RAW 264.7 microphages
Concentration: 12.5 μM
Incubation Time: 24 hours
Result: Inhibited the expression of TNF-α, IL-6, and IL-1β at 12.5 µM.
In Vivo

iNOs-IN-3 (oral administration; 12.5 mg/kg; once) treatment shows anti-inflammatory activity against xylene-induced ear edema in mice[1].
iNOs-IN-3 (oral administration; 3.125 mg/kg, 6.25 mg/kg, 12.5 mg/kg; once) protects against LPS-induced acute lung injury[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Xylene-induced mice[1]
Dosage: 12.5 mg/kg
Administration: Oral administration; 12.5 mg/kg; once
Result: Showed better activity than the positive control.
Animal Model: LPS-induced acute lung injury (ALI) mice[1]
Dosage: 3.125 mg/kg, 6.25 mg/kg, 12.5 mg/kg
Administration: Oral administration; 3.125 mg/kg, 6.25 mg/kg, 12.5 mg/kg; once
Result: Attenuated the pathological lesions dose-dependently, such as decreased inflammatory infiltration and pulmonary congestion. Inhibited LPS-induced lung edema dose-dependently.
Molecular Weight

488.55

Formula

C27H24N2O5S
CAS No.
SMILES

O=C1OC2=CC=CC(OS(=O)(C3=CC=CC4=C(N(C)C)C=CC=C43)=O)=C2N1CCC5=CC=CC=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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iNOs-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iNOs-IN-32241674-94-0NO SynthaseNitric oxide synthasesNOSanti-inflammatory activityacute lung injuryALIRAW 264.7Inhibitorinhibitorinhibit

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