Inositol nicotinate  (Synonyms: Inositol niacinate; Hexanicit)

Inositol nicotinate (Hexanicit) has vasodilating effects and can be used in research on peripheral arterial disease, showing efficacy when taken orally. Inositol nicotinate does not significantly improve triglyceride levels in mice induced by biphenyl esters^[1][2].

Inositol nicotinate (0.1-0.3 g/kg, oral , once a day, four days) shows no significant improvement in biphenyl ester-induced hypertriglyceridemia in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

810.72

C₄₂H₃₀N₆O₁₂

6556-11-2

Solid

White to off-white

O=C(C1=CC=CN=C1)O[C@H]2[C@@H](OC(C3=CC=CN=C3)=O)[C@@H](OC(C4=CC=CN=C4)=O)[C@H](OC(C5=CC=CN=C5)=O)[C@@H](OC(C6=CC=CN=C6)=O)[C@@H]2OC(C7=CC=CN=C7)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Si-Yuan Pan, et al.High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia. Acta Pharmacol Sin. 2006 Jun;27(6):673-8.  [Content Brief]

  [2]. H Squires, et al. A systematic review and economic evaluation of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease. NIHR Health Technology Assessment programme: Executive Summaries.  [Content Brief]