Inuviscolide

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Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G₂/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities.

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Inuviscolide Chemical Structure

CAS No. : 63109-30-8

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Description

Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G₂/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities^[1]^[2]^[3].

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	21.9 μM Compound: 21	Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction	[PMID: 21894898]
RAW264.7	IC₅₀	9.64 μM Compound: 20	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method	[PMID: 21924800]

In Vitro

Inuviscolide (9-72 μM; 24 h) inhibits the proliferation of SK-28, 624 and 1363 melanoma cells, with IC₅₀s of 37, 41.1, and 39 μM, respectively^[2].
Inuviscolide (36-54 μM; 4-24 h) leads to a dose-dependent accumulation of SK-28 cells at the G₂/M phase^[2].
Inuviscolide (72 μM; 48 h) results in ~70% of SK-28 cells exhibiting markers of early apoptosis^[2].
Inuviscolide inhibits the release of human leukocyte elastase by 51% at 100 μM^[1].
Inuviscolide inhibits secretory PLA₂ (sPLA₂) from bee venom, with an IC₅₀ of 80.5 μM^[1].
Inuviscolide inhibits COX-1 at 50 μM (40%), while it is inactive on the inducible form, COX-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:	SK-28, 624 and 1363 melanoma cells
Concentration:	9-72 μM
Incubation Time:	24 hours
Result:	Resulted in a dose-dependent inhibition of cellular proliferation, with no significant changes between the three cell lines.

In Vivo

Inuviscolide reduces the skin leukocyte infiltration in a murine model of dermatitis induced by repeated application of 12-O-tetradecanoylphorbol 13-acetate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

248.32

Formula

C₁₅H₂₀O₃

CAS No.

63109-30-8

SMILES

C[C@@]1([C@@]2([H])[C@@](CC1)([H])C(C[C@@]3([H])[C@](C(C(O3)=O)=C)([H])C2)=C)O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Máñez S, et, al. Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa. Fitoterapia. 2007 Jun;78(4):329-31. [Content Brief]

[2]. Rozenblat S, et, al. Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines. Biochem Pharmacol. 2008 Jan 15;75(2):369-82. [Content Brief]

[3]. Hernández V, et, al. A mechanistic approach to the in vivo anti-inflammatory activity of sesquiterpenoid compounds isolated from Inula viscosa. Planta Med. 2001 Nov;67(8):726-31. [Content Brief]

Inuviscolide Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inuviscolide63109-30-8ApoptosisG2/Mmelanoma cellantineoplasticanti-inflammatoryInhibitorinhibitorinhibit

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Inuviscolide

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