Irisquinone

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Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks.

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Irisquinone Chemical Structure

CAS No. : 56495-82-0

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Description

Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks^[1]^[2]^[3].

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	EC₅₀	5.52 μM Compound: 22	Antiproliferative activity against human A375 cells after 72 hrs by MTT assay Antiproliferative activity against human A375 cells after 72 hrs by MTT assay	[PMID: 25826398]
A549	EC₅₀	3.25 μM Compound: 22	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 25826398]
HaCaT	EC₅₀	11.4 μM Compound: 22	Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay	[PMID: 25826398]
HCT-116	EC₅₀	4.19 μM Compound: 22	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 25826398]
HFF-1	EC₅₀	14.8 μM Compound: 22	Antiproliferative activity against HFF1 cells after 72 hrs by MTT assay Antiproliferative activity against HFF1 cells after 72 hrs by MTT assay	[PMID: 25826398]
MCF-10A	EC₅₀	26.4 μM Compound: 22	Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay	[PMID: 25826398]
SK-MEL-2	EC₅₀	4.4 μM Compound: 22	Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by MTT assay Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by MTT assay	[PMID: 25826398]

In Vitro

Irisquinone (0-128 nM, 12-48 h) induces cell death of C6 rat glioma cells^[2].
Irisquinone (4.2 nM, 48 h) increases the radiosensitivity of C6 rat glioma cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	C6 rat glioma cells
Concentration:	0, 4, 8, 16, 32, 64, 128 nM
Incubation Time:	12, 24, 48 h
Result:	Time-dependently and dose-dependently inhibited cell viability.

In Vivo

Irisquinone (12.5 mg/kg, perfused daily) makes the rabbit VX2 lung transplant tumor wall thinner and the necrotic area larger in the irisquinone + radiotherapy group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rabbit bearing VX2 lung transplant tumor^[1]
Dosage:	12.5 mg/kg
Administration:	Perfused daily, starting from 3 days before irradiation to the end of irradiation.
Result:	Displayed no significant difference of tumor growth between the radio therapy and Irisquinone + radiotherapy groups. Showed thinner tumor wall and the larger necrotic area in the Irisquinone + radiotherapy group.

Molecular Weight

374.56

Formula

C₂₄H₃₈O₃

CAS No.

56495-82-0

SMILES

O=C1C(CCCCCCCCC/C=C\CCCCCC)=CC(C=C1OC)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu H, et al. Dynamic observation of the radiosensitive effect of irisquinone on rabbit VX2 lung transplant tumors by using fluorine-18-deoxyglucose positron emission tomography/computed tomography. Nucl Med Commun. 2013 Mar;34(3):220-8. [Content Brief]

[2]. Wang H, et al. Radiosensitizing effect of irisquinone on glioma through the downregulation of HIF-1α evaluated by 18F-FDG and 18F-FMISO PET/CT. Nucl Med Commun. 2016 Jul;37(7):705-14. [Content Brief]

[3]. Liang, l., et al. The effect of Irisquinone on the glutathione system and MRP expression of cisplatin-resistant human lung adenocarcinoma cell line (A DDP549). Chin J Cancer Res 13, 171–175 (2001).

Irisquinone Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Irisquinone56495-82-0OthersC6 rat gliomaradiation sensitizeranticancerGSHInhibitorinhibitorinhibit

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