Isorhamnetin 3-glucuronide (Synonyms: Isorhamnetin 3-O-glucuronide)

Cat. No.: HY-126423: FAQs
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Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase.

For research use only. We do not sell to patients.

Isorhamnetin 3-glucuronide Chemical Structure

CAS No. : 36687-76-0

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Other Forms of Isorhamnetin 3-glucuronide:

Isorhamnetin 3-glucuronide-d3 Get quote

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Description

In Vitro

Isorhamnetin 3-glucuronide (0-100 µM; 48 h) shows anti-proliferative activity in a dose-dependent manner for MCF-7 cells^[1].
Isorhamnetin 3-glucuronide (0-100 µM; 48 h) induces apoptosis and cell cycle arrest at S-phase in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MCF-7 cells
Concentration:	0, 25, 50, 100 µM
Incubation Time:	48 h
Result:	Inhibited cell proliferation in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:	MCF-7 cells
Concentration:	25, 100 µM
Incubation Time:	48 h
Result:	Induced apoptosis with the rate of 16.8%, 49.8% at 25, 100 µM, respectively.

Cell Cycle Analysis^[1]

Cell Line:	MCF-7 cells
Concentration:	0, 50, 100 µM
Incubation Time:	48 h
Result:	Induced cell cycle arrest at S-phase.

Molecular Weight

492.39

Formula

C₂₂H₂₀O₁₃

CAS No.

36687-76-0

SMILES

O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=C(C3=CC=C(O)C(OC)=C3)OC4=CC(O)=CC(O)=C4C2=O

Structure Classification

Initial Source

Endogenous metabolite

human plasma

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu Q, et al. Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells. J Agric Food Chem. 2018 Jul 11;66(27):7181-7189. [Content Brief]

Isorhamnetin 3-glucuronide Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isorhamnetin 3-glucuronide36687-76-0Isorhamnetin 3-O-glucuronideOthersanti-proliferativeapoptosisMCF-7 cellsS-phaseInhibitorinhibitorinhibit

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