IV-23

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IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC).

For research use only. We do not sell to patients.

IV-23 Chemical Structure

CAS No. : 2326007-49-0

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.82 μM Compound: 9d	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
A549	IC₅₀	6.82 μM Compound: 9d	Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
ECa-109 cell line	IC₅₀	2.24 μM Compound: 9d	Antiproliferative activity against human Eca-109 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human Eca-109 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
ECa-109 cell line	IC₅₀	2.24 μM Compound: 9d	Antiproliferative activity against human Eca-109 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human Eca-109 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
KYSE-30	IC₅₀	1.61 μM Compound: 9d	Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
KYSE-30	IC₅₀	1.61 μM Compound: 9d	Antiproliferative activity against human KYSE-30 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-30 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
KYSE-450	IC₅₀	1.49 μM Compound: 9d	Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
KYSE-450	IC₅₀	1.49 μM Compound: 9d	Antiproliferative activity against human KYSE-450 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-450 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
KYSE-510	IC₅₀	2.08 μM Compound: 9d	Antiproliferative activity against human KYSE-510 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-510 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
KYSE-510	IC₅₀	2.08 μM Compound: 9d	Antiproliferative activity against human KYSE-510 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-510 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
MGC-803	IC₅₀	1.84 μM Compound: 9d	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
MGC-803	IC₅₀	1.84 μM Compound: 9d	Antiproliferative activity against human MGC-803 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human MGC-803 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]

In Vitro

IV-23 (Compound 20) shows a strong inhibition against the ESCCs in a concentration depend manner, the IC₅₀ values against the Kyse30 and Kyse450 cell lines were all less than 2 μM, presented in a dose-dependent manner. IV-23 triggeres caspases related apoptosis in ESCC cells^[1].
IV-23 induces G2/M phase arrest^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

392.24

Formula

C₁₈H₁₈BrNO₄

CAS No.

2326007-49-0

SMILES

O=C(N1CCC2=C1C=CC(Br)=C2)C3=CC(OC)=C(OC)C(OC)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fu DJ, et al. Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis. Bioorg Chem. 2019 Aug 10;92:103190. [Content Brief]

IV-23 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IV-232326007-49-0IV23IV 23ApoptosisInhibitorinhibitorinhibit

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