2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC DNA Methyltransferase Apoptosis
  4. J208

J208 is a dual inhibitor for histone deacetylase (HDAC) and DNA methyltransferase (DNMT). J208 inhibits proliferation of cancer cells, as well as the migration/invasion of triple-negative breast cancer (TNBC) cells. J208 induces apoptosis, arrests the cell cycle at G0/G1 phase. J2008 activates the innate immune signalling pathway in TNBC, by inducing the expression of endogenous retroviruses (ERVs).

For research use only. We do not sell to patients.

J208 Chemical Structure

J208 Chemical Structure

CAS No. : 2116468-11-0

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J208 Related Antibodies

Top Publications Citing Use of Products

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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DNA Methyltransferase DNMT1 DNMT3 MGMT

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Description

J208 is a dual inhibitor for histone deacetylase (HDAC) and DNA methyltransferase (DNMT). J208 inhibits proliferation of cancer cells, as well as the migration/invasion of triple-negative breast cancer (TNBC) cells. J208 induces apoptosis, arrests the cell cycle at G0/G1 phase. J2008 activates the innate immune signalling pathway in TNBC, by inducing the expression of endogenous retroviruses (ERVs)[1].

IC50 & Target

HDAC1

 

Molecular Weight

412.44

Formula

C20H24N6O4
CAS No.
SMILES

O=C1C=CN(C(N1)=O)CC2=CC=C(C=C2)C3=CN(N=N3)CCCCCCC(NO)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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J208 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

J2082116468-11-0J 208J-208HDACDNA MethyltransferaseApoptosisHistone deacetylasesDNMTsDNA MTasesTNBCtriple-negative breast cancerBT-549HCC1937MDA-MB-231Inhibitorinhibitorinhibit

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