2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. JAK 3i

JAK3i is a highly selective JAK3 inhibitor (IC50: 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for  autoimmune disease research.

For research use only. We do not sell to patients.

JAK 3i Chemical Structure

JAK 3i Chemical Structure

CAS No. : 1918238-72-8

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Based on 1 publication(s) in Google Scholar

JAK 3i Related Antibodies

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Description

JAK3i is a highly selective JAK3 inhibitor (IC50: 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for  autoimmune disease research[1].

IC50 & Target[1]

JAK3

0.43 nM (IC50)

JAK2

8680 nM (IC50)

JAK1

1520 nM (IC50)

Molecular Weight

354.34

Formula

C18H15FN4O3
CAS No.
SMILES

CCOC(C1=CN=C2C1=C(C3=C(F)C=CC(NC(C=C)=O)=C3)NC=N2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JAK 3i Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK 3i1918238-72-8JAKJanus kinaseJAK3Immune diseaseT-cell proliferationpSTAT5stat5Inhibitorinhibitorinhibit

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