2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt JAK/STAT Signaling Epigenetics Apoptosis
  3. FLT3 JAK Apoptosis
  4. JAK2/FLT3-IN-3

JAK2/FLT3-IN-3 (11r) is a dual FLT3 and JAK2 inhibitor, with IC50 values of 2.01 nM, 0.51 nM and 104.40 nM for JAK2, FLT3 and JAK3, respectively. JAK2/FLT3-IN-3 (11r) induces apoptosis and possesses antitumor activity.

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JAK2/FLT3-IN-3 Chemical Structure

JAK2/FLT3-IN-3 Chemical Structure

CAS No. : 3038183-53-5

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JAK2/FLT3-IN-3 Related Antibodies

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Description

JAK2/FLT3-IN-3 (11r) is a dual FLT3 and JAK2 inhibitor, with IC50 values of 2.01 nM, 0.51 nM and 104.40 nM for JAK2, FLT3 and JAK3, respectively. JAK2/FLT3-IN-3 (11r) induces apoptosis and possesses antitumor activity[1].

IC50 & Target[1]

JAK2

2.01 nM (IC50)

FLT3

0.51 nM (IC50)

JAK3

104.40 nM (IC50)

In Vitro

JAK2/FLT3-IN-3 (11r) exerts potent antiproliferative activity against HEL (IC50 = 1.1 μM), MV4-11 (IC50 = 9.43 nM), RPMI-8226 (IC50 = 0.793 μM), NCI-H929 (IC50 = 0.743 μM), Ba/F3-FLT3-ITD-D835Y (IC50 = 0.099 μM), and Ba/F3-FLT3-ITD-F691L (IC50 = 0.042 μM) cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JAK2/FLT3-IN-3 Related Antibodies
In Vivo

JAK2/FLT3-IN-3 (11r) shows moderate absorption (Tmax = 5.33 h), with a peak concentration of 38.7 ng/mL and an AUC of 522 ng h/mL in rats, and an oral bioavailability of 25.2%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

611.78

Formula

C34H45N9O2
CAS No.
SMILES

O=C(NC1=CC=C(C(C)=O)C=C1)N(CC2)CCN2C3=NC(NC4=CC=C(N5CCC(N6CCN(C)CC6)CC5)C=C4)=NC=C3C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JAK2/FLT3-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK2/FLT3-IN-33038183-53-5FLT3JAKApoptosisCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Janus kinaseHELMV4-11RPMI-8226NCI-H929JAK2Inhibitorinhibitorinhibit

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