JNJ-42314415

Cat. No.: HY-123743: FAQs
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JNJ-42314415 is a centrally active phosphodiesterase 10A (PDE10A) inhibitor, with K_i values of 35 nM and 64 nM for human recombinant PDE10A and rPDE10A, respectively.

For research use only. We do not sell to patients.

JNJ-42314415 Chemical Structure

CAS No. : 1334165-90-0

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Biological Activity
Purity & Documentation
References
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Description

JNJ-42314415 is a centrally active phosphodiesterase 10A (PDE10A) inhibitor, with K_i values of 35 nM and 64 nM for human recombinant PDE10A and rPDE10A, respectively^[1].

IC₅₀ & Target^[1]

human PDE 10A

35 nM (Ki)

Cellular Effect

Cell Line	Type	Value	Description	References
Sf21	IC₅₀	190 nM Compound: Figure 27, R1C3	Inhibition of rat recombinant PDE10A2 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 60 mins by scintillation proximity assay Inhibition of rat recombinant PDE10A2 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 60 mins by scintillation proximity assay	[PMID: 22834877]

In Vivo

JNJ-42314415 with high dose (24.7 mg/kg) induces hypothermia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

353.42

Formula

C₁₉H₂₃N₅O₂

CAS No.

1334165-90-0

SMILES

CC1=C(N2C(C(N3CCOCC3)=NC=C2)=N1)C4=CC=C(N=C4)CCOC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Anton A H P Megens, et al. Pharmacology of JNJ-42314415, a centrally active phosphodiesterase 10A (PDE10A) inhibitor: a comparison of PDE10A inhibitors with D2 receptor blockers as potential antipsychotic drugs. J Pharmacol Exp Ther. 2014 Apr;349(1):138-54. [Content Brief]

JNJ-42314415 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-423144151334165-90-0JNJ42314415JNJ 42314415Phosphodiesterase (PDE)phosphodiesterase 10APDE10Ahypothermiaantipsychotic drugInhibitorinhibitorinhibit

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