2. MAPK/ERK Pathway
  3. MAP3K
  4. JT21-25

JT21-25 (compound 9h) is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with IC50 of 5.1 nM.

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JT21-25 Chemical Structure

JT21-25 Chemical Structure

CAS No. : 2996864-57-2

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JT21-25 Related Antibodies

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MAP3K7/TAK1 MAP3K8 ASK2 MAP3K5/ASK1

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Description

JT21-25 (compound 9h) is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with IC50 of 5.1 nM[1].

IC50 & Target

ASK1

5.1 nM (IC50)

Molecular Weight

437.29

Formula

C20H17BrN6O
CAS No.
SMILES

BrC1=CC=CC2=C1N=C(C(NC3=NC(C4=NN=CN4C(C)C)=CC=C3)=O)C=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JT21-25 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JT21-252996864-57-2MAP3KMAP kinase kinase kinase, MEKK, MAPKKKLO2 liver cellslow cytometry cell cycleoil red O stainingInhibitorinhibitorinhibit

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JT21-25
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HY-161283
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