2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. JYQ-173

JYQ-173 is a selective inhibitor for human Parkinson disease protein 7 (PARK7), with an IC50 of 19 nM. JYQ-173 exhibits good cell permeability. JYQ-173 is the ligand for target protein PARK7, which can be utilized for synthesis of PROTAC Degrader JYQ-194 (HY-163564).

For research use only. We do not sell to patients.

JYQ-173 Chemical Structure

JYQ-173 Chemical Structure

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JYQ-173 Related Antibodies

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Description

JYQ-173 is a selective inhibitor for human Parkinson disease protein 7 (PARK7), with an IC50 of 19 nM. JYQ-173 exhibits good cell permeability. JYQ-173 is the ligand for target protein PARK7, which can be utilized for synthesis of PROTAC Degrader JYQ-194 (HY-163564)[1].

IC50 & Target

IC50: 19 nM (PARK7)
Molecular Weight

466.49

Formula

C21H19FN8O2S
SMILES

O=C([C@H]1CN(C#N)CC1)NC(S2)=NC3=C2CN(C(C4=C(F)C=CC(N5C=CN=N5)=C4)=O)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JYQ-173 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JYQ-173JYQ173JYQ 173Ligands for Target Protein for PROTACTarget Protein-binding MoietyUbiquitinationDegradationCancerNeurodegenerative DiseasesParkinson's diseaseA549Inhibitorinhibitorinhibit

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HY-163563
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