2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. K1586

K1586 is an amidine derivative that efficiently targets Chk1. K1586 enhances the degradation of Chk1 that sensitizes colorectal cancer cells to ionizing radiation. K1586 shows anticancer effects.

For research use only. We do not sell to patients.

K1586 Chemical Structure

K1586 Chemical Structure

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K1586 Related Antibodies

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Description

K1586 is an amidine derivative that efficiently targets Chk1. K1586 enhances the degradation of Chk1 that sensitizes colorectal cancer cells to ionizing radiation. K1586 shows anticancer effects[1].

In Vitro

K1586 (0.001-100 μM; 72 h) decreases cell proliferation in a dose-dependent manner[1].
K1586 (10-20 μM; 24 h) increases the relative length of the S phase and significant increases the length of the G2/M phase[1].
K1586 (10 μM; 12 h) decreases Chk1 protein levels in a time-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

K1586 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HT29 human colorectal cancer cells
Concentration: 0.001 μM, 0.01 μM, 0.1 μM, 1 μM, 5 μM, 10 μM, 50 μM, and 100 μM
Incubation Time: 72 h
Result: Proliferation decreased in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: HT29 cells
Concentration: 10 or 20 μM
Incubation Time: 24 h
Result: Increased the length of the G2/M phase in cells.

Western Blot Analysis[1]

Cell Line: HT29 cells
Concentration: 10 μM
Incubation Time: 12 h
Result: Induced Chk1 destabilization and degradation.
Molecular Weight

359.87

Formula

C18H18ClN3OS
SMILES

CCN(CC)/C=N/C(C=C1)=CC2=C1N=C(S2)OC3=CC=C(Cl)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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K1586 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K1586K 1586K-1586Checkpoint Kinase (Chk)anticancer agentChk1 inhibitorionizing radiationamidine derivativeInhibitorinhibitorinhibit

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